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PF-05212384

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For Research Use Only | Not For Clinical Use
CATAP1197160783
CAS1197160-78-3
Molecular Weight615.73
Description≥98% (HPLC)
SolubilityDMSO: 0.5 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

A Multi-Arm Phase I Study of the PI3K/mTOR Inhibitors PF-04691502 and Gedatolisib (PF-05212384) Plus Irinotecan or the MEK Inhibitor PD-0325901 in Advanced Cancer

Zev A Wainberg, Maria Alsina, Heloisa P Soares, Irene Braña, Carolyn D Britten, Gianluca Del Conte, Patrick Ezeh, Brett Houk, Kenneth A Kern, Stephen Leong, Nuzhat Pathan, Kristen J Pierce, Lillian L Siu, etc.

Target Oncol. 2017 Dec;12(6):775-785.

PMID: 29067643

1

A Randomized Phase II Non-Comparative Study of PF-04691502 and Gedatolisib (PF-05212384) in Patients With Recurrent Endometrial Cancer

Josep María Del Campo, Michael Birrer, Craig Davis, Keiichi Fujiwara, Ashwin Gollerkeri, Martin Gore, Brett Houk, Susie Lau, Andres Poveda, Antonio González-Martín, Carolyn Muller, Kei Muro, Kristen Pierce, etc.

Gynecol Oncol. 2016 Jul;142(1):62-69.

PMID: 27103175

1

Bioanalysis of Targeted Nanoparticles in Monkey Plasma via LC-MS/MS

Wei Song, Joseph A Tweed, Ravi Visswanathan, James P Saunders, Zhenhua Gu, Christopher L Holliman

Anal Chem. 2019 Nov 5;91(21):13874-13882.

PMID: 31584812

1

Evaluation of the Dual mTOR/PI3K Inhibitors Gedatolisib (PF-05212384) and PF-04691502 Against Ovarian Cancer Xenograft Models

Simon P Langdon, Charlene Kay, In Hwa Um, Michael Dodds, Morwenna Muir, Grant Sellar, Julie Kan, Charlie Gourley, David J Harrison

Sci Rep. 2019 Dec 10;9(1):18742.

PMID: 31822716

1

First-in-Human Study of PF-05212384 (PKI-587), a Small-Molecule, Intravenous, Dual Inhibitor of PI3K and mTOR in Patients With Advanced Cancer

Geoffrey I Shapiro, Katherine M Bell-McGuinn, Julian R Molina, Johanna Bendell, James Spicer, Eunice L Kwak, Susan S Pandya, Robert Millham, Gary Borzillo, Kristen J Pierce, Lixin Han, Brett E Houk, Jorge D Gallo, etc.

Clin Cancer Res. 2015 Apr 15;21(8):1888-95.

PMID: 25652454

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