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PF-06273340

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For Research Use Only | Not For Clinical Use
CATAP1402438747
CAS1402438-74-7
Molecular Weight479.92
InChI KeyBPIWZDNVMQQBQX-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Color, white to yellow to brown
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

Demonstration of an Anti-Hyperalgesic Effect of a Novel pan-Trk Inhibitor PF-06273340 in a Battery of Human Evoked Pain Models

Peter Loudon, Pieter Siebenga, Donal Gorman, Katrina Gore, Pinky Dua, Guido van Amerongen, Justin L Hay, Geert Jan Groeneveld, Richard P Butt

Br J Clin Pharmacol. 2018 Feb;84(2):301-309.

PMID: 29178434

1

Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain

Sharan K Bagal, Mark Andrews, Bruce M Bechle, Jianwei Bian, James Bilsland, David C Blakemore, John F Braganza, Peter J Bungay, Matthew S Corbett, Ciaran N Cronin, Jingrong Jean Cui, Rebecca Dias, Neil J Flanagan, etc.

J Med Chem. 2018 Aug 9;61(15):6779-6800.

PMID: 29944371

1

Relevance of Neurotrophin Receptors CD271 and TrkC for Prognosis, Migration, and Proliferation in Head and Neck Squamous Cell Carcinoma

Yannick Foerster, Timo Stöver, Jens Wagenblast, Marc Diensthuber, Sven Balster, Jennis Gabrielpillai, Hannah Petzold, Christin Geissler

Cells. 2019 Sep 28;8(10):1167.

PMID: 31569361

1

The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain

Sarah E Skerratt, Mark Andrews, Sharan K Bagal, James Bilsland, David Brown, Peter J Bungay, Susan Cole, Karl R Gibson, Russell Jones, Inaki Morao, Angus Nedderman, Kiyoyuki Omoto, Colin Robinson, Thomas Ryckmans, etc.

J Med Chem. 2016 Nov 23;59(22):10084-10099.

PMID: 27766865

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