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PF-06282999

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For Research Use Only | Not For Clinical Use
CATAP1435467370
CAS1435467-37-0
MDL NumberMFCD30533689
Molecular Weight325.77
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG
Storage Conditionsroom temp
1

Establishing Transcriptional Signatures to Differentiate PXR-, CAR-, and AhR-Mediated Regulation of Drug Metabolism and Transport Genes in Cryopreserved Human Hepatocytes

Jamie E Moscovitz, Amit S Kalgutkar, Kelly Nulick, Nathaniel Johnson, Zhiwu Lin, Theunis C Goosen, Yan Weng

J Pharmacol Exp Ther. 2018 May;365(2):262-271.

PMID: 29440451

1

Examination of the Human Cytochrome P4503A4 Induction Potential of PF-06282999, an Irreversible Myeloperoxidase Inactivator: Integration of Preclinical, In Silico, and Biomarker Methodologies in the Prediction of the Clinical Outcome

Jennifer Q Dong, James R Gosset, Odette A Fahmi, Zhiwu Lin, Jeffrey R Chabot, Steven G Terra, Vu Le, Kristin Chidsey, Parya Nouri, Albert Kim, Leonard Buckbinder, Amit S Kalgutkar

Drug Metab Dispos. 2017 May;45(5):501-511.

PMID: 28254951

1

Induction of Human Cytochrome P450 3A4 by the Irreversible Myeloperoxidase Inactivator PF-06282999 Is Mediated by the Pregnane X Receptor

Jamie E Moscovitz, Zhiwu Lin, Nathaniel Johnson, Meihua Tu, Theunis C Goosen, Yan Weng, Amit S Kalgutkar

Xenobiotica. 2018 Jul;48(7):647-655.

PMID: 28685622

1

Myeloperoxidase Inhibition in Mice Alters Atherosclerotic Lesion Composition

Rachel J Roth Flach, Chunyan Su, Eliza Bollinger, Christian Cortes, Andrew W Robertson, Alan C Opsahl, Timothy M Coskran, Kevin P Maresca, Edmund J Keliher, Phillip D Yates, Albert M Kim, Amit S Kalgutkar, etc.

PLoS One. 2019 Mar 19;14(3):e0214150.

PMID: 30889221

1

Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans

Jennifer Q Dong, Manthena V Varma, Angela Wolford, Tim Ryder, Li Di, Bo Feng, Steven G Terra, Kazuko Sagawa, Amit S Kalgutkar

Drug Metab Dispos. 2016 Feb;44(2):209-19.

PMID: 26608081

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