0

PF-06409577

INQUIRY Add to cart
For Research Use Only | Not For Clinical Use
CATAP1467057233
CAS1467057-23-3
Molecular Weight341.79
InChI KeyFHQXLWCFSUSXBF-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1 H-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to β-Estradiol

Kimberly Lapham, Jian Lin, Jonathan Novak, Christine Orozco, Mark Niosi, Li Di, Theunis C Goosen, Sangwoo Ryu, Keith Riccardi, Heather Eng, Kimberly O Cameron, Amit S Kalgutkar

Drug Metab Dispos. 2018 Dec;46(12):1836-1846.

PMID: 30194276

1

Activation of Liver AMPK With PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models

Ryan M Esquejo, Christopher T Salatto, Jake Delmore, Bina Albuquerque, Allan Reyes, Yuji Shi, Rob Moccia, Emily Cokorinos, Matthew Peloquin, Mara Monetti, Jason Barricklow, Eliza Bollinger, Brennan K Smith, etc.

EBioMedicine. 2018 May;31:122-132.

PMID: 29673898

1

Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives Are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK)

Tim F Ryder, Matthew F Calabrese, Gregory S Walker, Kimberly O Cameron, Allan R Reyes, Kris A Borzilleri, Jake Delmore, Russell Miller, Ravi G Kurumbail, Jessica Ward, Daniel W Kung, Janice A Brown, David J Edmonds, etc.

J Med Chem. 2018 Aug 23;61(16):7273-7288.

PMID: 30036059

1

Direct Activation of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by PF-06409577 Inhibits Flavivirus Infection Through Modification of Host Cell Lipid Metabolism

Nereida Jiménez de Oya, Ana-Belén Blázquez, Josefina Casas, Juan-Carlos Saiz, Miguel A Martín-Acebes

Antimicrob Agents Chemother. 2018 Jun 26;62(7):e00360-18.

PMID: 29712653

1

PF-06409577 Activates AMPK Signaling to Protect Retinal Pigment Epithelium Cells From UV Radiation

Xiao-Feng Li, Xiu-Ming Liu, Da-Rui Huang, Hai-Jing Cao, Jun-Ying Wang

Biochem Biophys Res Commun. 2018 Jun 18;501(1):293-299.

PMID: 29733844

  • Verification code
Contact Us

Send Us a Request

What is your specific need? We will do everything we can to meet your expectations.
Online Inquiry

Online Inquiry

For any inquiry, question or recommendation, please call: or fill out the following form.

  • Verification code

Head Office

  • Tel:
  • Email:

Follow us on

qrcode