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PF-06459988

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For Research Use Only | Not For Clinical Use
CATAP1428774451
CAS1428774-45-1
MDL NumberMFCD28987462
Molecular Weight431.88
InChI KeyODMXWZROLKITMS-RISCZKNCSA-N
Description≥98% (HPLC)
SolubilityDMSO: 5 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

Hengmiao Cheng, Sajiv K Nair, Brion W Murray, Chau Almaden, Simon Bailey, Sangita Baxi, Doug Behenna, Sujin Cho-Schultz, Deepak Dalvie, Dac M Dinh, Martin P Edwards, Jun Li Feng, Rose Ann Ferre, Ketan S Gajiwala, etc.

J Med Chem. 2016 Mar 10;59(5):2005-24.

PMID: 26756222

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