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PF-06651600

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For Research Use Only | Not For Clinical Use
CATALP1792180814
CAS1792180-81-4 (free base)
Molecular Weight389.41
InChI KeyQMPMPSGDPRHZCG-VZXYPILPSA-N
Description≥98% (HPLC)
SolubilityH2O: 5 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition Over pan-JAK or JAK1-Selective Inhibition

Jean-Baptiste Telliez, Martin E Dowty, Lu Wang, Jason Jussif, Tsung Lin, Li Li, Erick Moy, Paul Balbo, Wei Li, Yajuan Zhao, Kimberly Crouse, Caitlyn Dickinson, Peter Symanowicz, Martin Hegen, Mary Ellen Banker, etc.

ACS Chem Biol. 2016 Dec 16;11(12):3442-3451.

PMID: 27791347

1

Jak3 Deficiency Blocks Innate Lymphoid Cell Development

M L Robinette, M Cella, J B Telliez, T K Ulland, A D Barrow, K Capuder, S Gilfillan, L-L Lin, L D Notarangelo, M Colonna

Mucosal Immunol. 2018 Jan;11(1):50-60.

PMID: 28513593

1

Janus Kinase Inhibitors for the Treatment of Inflammatory Bowel Diseases: Developments From Phase I and Phase II Clinical Trials

Ferdinando D'Amico, Gionata Fiorino, Federica Furfaro, Mariangela Allocca, Silvio Danese

Expert Opin Investig Drugs. 2018 Jul;27(7):595-599.

PMID: 29938545

1

PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor

Hua Xu, Michael I Jesson, Uthpala I Seneviratne, Tsung H Lin, M Nusrat Sharif, Liang Xue, Chuong Nguyen, Robert A Everley, John I Trujillo, Douglas S Johnson, Gary R Point, Atli Thorarensen, Iain Kilty, etc.

ACS Chem Biol. 2019 Jun 21;14(6):1235-1242.

PMID: 31082193

1

Scoping Review on the Use of Drugs Targeting JAK/STAT Pathway in Atopic Dermatitis, Vitiligo, and Alopecia Areata

Ana M Montilla, Francisco Gómez-García, Pedro J Gómez-Arias, Jesús Gay-Mimbrera, Jorge Hernández-Parada, Beatriz Isla-Tejera, Juan Ruano

Dermatol Ther (Heidelb). 2019 Dec;9(4):655-683.

PMID: 31606872

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