PF-06747775

INQUIRY Add to cart

For Research Use Only | Not For Clinical Use

CAT	AP1776112903
CAS	1776112-90-3
Molecular Weight	415.42
InChI Key	JYIUNVOCEFIUIU-GHMZBOCLSA-N

Description	≥98% (HPLC)
Solubility	DMSO: 20 mg/mL, clear
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG
Storage Conditions	room temp

Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) Through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants With Selectivity Over Wild-Type EGFR

Simon Planken, Douglas C Behenna, Sajiv K Nair, Theodore O Johnson, Asako Nagata, Chau Almaden, Simon Bailey, T Eric Ballard, Louise Bernier, Hengmiao Cheng, Sujin Cho-Schultz, Deepak Dalvie, Judith G Deal, etc.

J Med Chem. 2017 Apr 13;60(7):3002-3019.

PMID: 28287730

Recent Updates on Third Generation EGFR Inhibitors and Emergence of Fourth Generation EGFR Inhibitors to Combat C797S Resistance

Harun Patel, Rahul Pawara, Azim Ansari, Sanjay Surana

Eur J Med Chem. 2017 Dec 15;142:32-47.

PMID: 28526474

Third-generation Inhibitors Targeting EGFR T790M Mutation in Advanced Non-Small Cell Lung Cancer

Shuhang Wang, Shundong Cang, Delong Liu

J Hematol Oncol. 2016 Apr 12;9:34.

PMID: 27071706

* Products or Services Interested: PF-06747775 (1776112-90-3)
* Your question
* Name
* Email
Verification Code

Send Us a Request

What is your specific need? We will do everything we can to meet your expectations.

Online Inquiry