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PF-06767832

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For Research Use Only | Not For Clinical Use
CATAP1859081585
CAS1859081-58-5
Molecular Weight409.50
InChI KeyVVZZHFMLRHJXTO-RXVVDRJESA-N
Description≥98% (HPLC)
SolubilityDMSO: 30 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects

Jennifer E Davoren, Che-Wah Lee, Michelle Garnsey, Michael A Brodney, Jason Cordes, Keith Dlugolenski, Jeremy R Edgerton, Anthony R Harris, Christopher J Helal, Stephen Jenkinson, Gregory W Kauffman, Terrence P Kenakin, etc.

J Med Chem. 2016 Jul 14;59(13):6313-28.

PMID: 27275946

1

Probing the binding site of novel selective positive allosteric modulators at the M 1 muscarinic acetylcholine receptor

Elham Khajehali, Celine Valant, Manuela Jörg, Andrew B Tobin, P Jeffrey Conn, Craig W Lindsley, Patrick M Sexton, Peter J Scammells, Arthur Christopoulos

Biochem Pharmacol. 2018 Aug;154:243-254.

PMID: 29777683

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