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PF-06827443

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For Research Use Only | Not For Clinical Use
CATIAR4244757
Molecular Weight404.46
Description≥98% (HPLC)
SolubilityDMSO: 10 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

A Novel M 1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity

Jerri M Rook, Jeanette L Bertron, Hyekyung P Cho, Pedro M Garcia-Barrantes, Sean P Moran, James T Maksymetz, Kellie D Nance, Jonathan W Dickerson, Daniel H Remke, Sichen Chang, Joel M Harp, Anna L Blobaum, etc.

ACS Chem Neurosci. 2018 Sep 19;9(9):2274-2285.

PMID: 29701957

1

Design and Synthesis of γ- and δ-Lactam M 1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M 1-Selective PAM with Weak Agonist Activity

Jennifer E Davoren, Michelle Garnsey, Betty Pettersen, Michael A Brodney, Jeremy R Edgerton, Jean-Philippe Fortin, Sarah Grimwood, Anthony R Harris, Stephen Jenkinson, Terry Kenakin, John T Lazzaro, Che-Wah Lee, etc.

J Med Chem. 2017 Aug 10;60(15):6649-6663.

PMID: 28598634

1

PF-06827443 Displays Robust Allosteric Agonist and Positive Allosteric Modulator Activity in High Receptor Reserve and Native Systems

Sean P Moran, Hyekyung P Cho, James Maksymetz, Daniel H Remke, Ryan M Hanson, Colleen M Niswender, Craig W Lindsley, Jerri M Rook, P Jeffrey Conn

ACS Chem Neurosci. 2018 Sep 19;9(9):2218-2224.

PMID: 29683646

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