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PF-4708671

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For Research Use Only | Not For Clinical Use
CATAP1255517760
CAS1255517-76-0
Structure
MDL NumberMFCD18086922
Molecular Weight390.41
InChI KeyFBLPQCAQRNSVHB-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: ≥20 mg/mL
Assay≥98% (HPLC)
Coloroff-white
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

Inhibition of Mitochondrial Complex 1 by the S6K1 Inhibitor PF-4708671 Partly Contributes to Its Glucose Metabolic Effects in Muscle and Liver Cells

Michael Shum, Vanessa P Houde, Vicky Bellemare, Rafael Junges Moreira, Kerstin Bellmann, Philippe St-Pierre, Benoit Viollet, Marc Foretz, André Marette

J Biol Chem. 2019 Aug 9;294(32):12250-12260.

PMID: 31243102

1

PF-4708671 Activates AMPK Independently of p70S6K1 Inhibition

Gilad W Vainer, Ann Saada, Juliane Kania-Almog, Adir Amartely, Jacob Bar-Tana, Rachel Hertz

PLoS One. 2014 Sep 9;9(9):e107364.

PMID: 25202971

1

PF-4708671, a Specific Inhibitor of p70 Ribosomal S6 Kinase 1, Activates Nrf2 by Promoting p62-dependent Autophagic Degradation of Keap1

Jeong Su Park, Dong Hoon Kang, Da Hyun Lee, Soo Han Bae

Biochem Biophys Res Commun. 2015 Oct 23;466(3):499-504.

PMID: 26381178

1

Protective Effects of PF-4708671 Against N-methyl-d-aspartic Acid-Induced Retinal Damage in Rats

Ikumi Hayashi, Yuto Aoki, Hiroko Ushikubo, Daiki Asano, Asami Mori, Kenji Sakamoto, Tsutomu Nakahara, Kunio Ishii

Fundam Clin Pharmacol. 2016 Dec;30(6):529-536.

PMID: 27371338

1

The p70S6K Specific Inhibitor PF-4708671 Impedes Non-Small Cell Lung Cancer Growth

Zhi-Xin Qiu, Rong-Fei Sun, Xian-Ming Mo, Wei-Min Li

PLoS One. 2016 Jan 15;11(1):e0147185.

PMID: 26771549

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