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PF-4778574

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For Research Use Only | Not For Clinical Use
CATAP1219633994
CAS1219633-99-4
Molecular Weight390.52
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

American Chemical Society-239th National meeting--Investigating New Therapeutic Candidates: Part 1. 21-25 March 2010, San Francisco, CA, USA

Donald Macauley

IDrugs. 2010 May;13(5):289-91.

PMID: 20432180

1

An Evaluation of Using Rat-Derived Single-Dose Neuropharmacokinetic Parameters to Project Accurately Large Animal Unbound Brain Drug Concentrations

Angela C Doran, Sarah M Osgood, Jessica Y Mancuso, Christopher L Shaffer

Drug Metab Dispos. 2012 Nov;40(11):2162-73.

PMID: 22899853

1

Positive Allosteric Modulation of AMPA Receptors From Efficacy to Toxicity: The Interspecies Exposure-Response Continuum of the Novel Potentiator PF-4778574

Christopher L Shaffer, Raymond S Hurst, Renato J Scialis, Sarah M Osgood, Dianne K Bryce, William E Hoffmann, John T Lazzaro, Ashley N Hanks, Susan Lotarski, Mark L Weber, JianHua Liu, Frank S Menniti, etc.

J Pharmacol Exp Ther. 2013 Oct;347(1):212-24.

PMID: 23899905

1

Positive Allosteric Modulation of AMPAR by PF-4778574 Produced Rapid Onset Antidepressant Actions in Mice

Mengxin Shen, Dan Lv, Shuting Li, Yanhua Zhang, Zhen Wang, Chiyu Zhao, Xuejie Chen, Chuang Wang

Cereb Cortex. 2019 Sep 13;29(10):4438-4451.

PMID: 30566581

1

Prevention of Ketamine-Induced Working Memory Impairments by AMPA Potentiators in a Nonhuman Primate Model of Cognitive Dysfunction

Brooke M Roberts, Daniel E Holden, Christopher L Shaffer, Patricia A Seymour, Frank S Menniti, Christopher J Schmidt, Graham V Williams, Stacy A Castner

Behav Brain Res. 2010 Sep 1;212(1):41-8.

PMID: 20347881

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