CAS 1817626-54-2 PF06650833 - Analytical Products / Alfa Chemistry

CAT	AP1817626542
CAS	1817626-54-2
Molecular Weight	361.37
InChI Key	JKDGKIBAOAFRPJ-ZBINZKHDSA-N

Description	≥98% (HPLC)
Solubility	DMSO: 20 mg/mL, clear
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG
Storage Conditions	room temp

1

Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Katherine L Lee, Catherine M Ambler, David R Anderson, Brian P Boscoe, Andrea G Bree, Joanne I Brodfuehrer, Jeanne S Chang, Chulho Choi, Seungwon Chung, Kevin J Curran, Jacqueline E Day, Christoph M Dehnhardt, etc.

J Med Chem. 2017 Jul 13;60(13):5521-5542.

PMID: 28498658

1

Inhibitors of interleukin-1 Receptor-Associated Kinase 4 (IRAK4): A Patent Review (2012-2015)

W Michael Seganish

Expert Opin Ther Pat. 2016 Aug;26(8):917-32.

PMID: 27310003

1

Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) Inhibitors: An Updated Patent Review (2016-2018)

William T McElroy

Expert Opin Ther Pat. 2019 Apr;29(4):243-259.

PMID: 30916602

1

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PF-06650833, a Selective interleukin-1 Receptor-Associated Kinase 4 (IRAK4) Inhibitor, in Single and Multiple Ascending Dose Randomized Phase 1 Studies in Healthy Subjects

Spencer I Danto, Negin Shojaee, Ravi Shankar P Singh, Cheryl Li, Steven A Gilbert, Zorayr Manukyan, Iain Kilty

Arthritis Res Ther. 2019 Dec 5;21(1):269.

PMID: 31805989

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