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PH-797804

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For Research Use Only | Not For Clinical Use
CATAP586379660
CAS586379-66-0
MDL NumberMFCD18251426
Molecular Weight477.30
Description≥98% (HPLC)
SolubilityDMSO: 10 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions20-25°C
1

Discovery of PH-797804, a Highly Selective and Potent Inhibitor of p38 MAP Kinase

Shaun R Selness, Rajesh V Devraj, Balekudru Devadas, John K Walker, Terri L Boehm, Richard C Durley, Huey Shieh, Li Xing, Paul V Rucker, Kevin D Jerome, Alan G Benson, Laura D Marrufo, Heather M Madsen, etc.

Bioorg Med Chem Lett. 2011 Jul 1;21(13):4066-71.

PMID: 21641211

1

In Vitro Metabolism Study of a Novel P38 Kinase Inhibitor: In Silico Predictions, Structure Elucidation Using MS/MS-I

Hanaa Ma Hashem, Marianne A Mahrouse

Future Med Chem. 2018 Jan;10(2):201-220.

PMID: 29239233

1

Inhibition of p38 MAPK in Combination With ART Reduces SIV-induced Immune Activation and Provides Additional Protection From Immune System Deterioration

Omkar Chaudhary, Vivek Narayan, Felipe Lelis, Brandon Linz, Meagan Watkins, Ronald Veazey, Anna Aldovini

PLoS Pathog. 2018 Aug 30;14(8):e1007268.

PMID: 30161247

1

Nanocrystals of a Potent p38 MAPK Inhibitor Embedded in Microparticles: Therapeutic Effects in Inflammatory and Mechanistic Murine Models of Osteoarthritis

Pierre Maudens, Christian Alexander Seemayer, François Pfefferlé, Olivier Jordan, Eric Allémann

J Control Release. 2018 Apr 28;276:102-112.

PMID: 29524442

1

Oral and Inhaled p38 MAPK Inhibitors: Effects on Inhaled LPS Challenge in Healthy Subjects

Dave Singh, Leonard Siew, Jared Christensen, Jonathan Plumb, Graham W Clarke, Steve Greenaway, Christelle Perros-Huguet, Nick Clarke, Iain Kilty, Lisa Tan

Eur J Clin Pharmacol. 2015 Oct;71(10):1175-84.

PMID: 26265232

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