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PHA-408

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For Research Use Only | Not For Clinical Use
CATAP503555553
CAS503555-55-3
Molecular Weight560.02
Description≥98% (HPLC)
SolubilityDMSO: 5 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

A Novel, Highly Selective, Tight Binding IkappaB kinase-2 (IKK-2) Inhibitor: A Tool to Correlate IKK-2 Activity to the Fate and Functions of the Components of the Nuclear factor-kappaB Pathway in Arthritis-Relevant Cells and Animal Models

Gabriel Mbalaviele, Cynthia D Sommers, Sheri L Bonar, Sumathy Mathialagan, John F Schindler, Julia A Guzova, Alexander F Shaffer, Michele A Melton, Lori J Christine, Catherine S Tripp, Po-Chang Chiang, etc.

J Pharmacol Exp Ther. 2009 Apr;329(1):14-25.

PMID: 19168710

1

Anti-inflammatory Effect of a Selective IkappaB Kinase-Beta Inhibitor in Rat Lung in Response to LPS and Cigarette Smoke

Saravanan Rajendrasozhan, Jae-Woong Hwang, Hongwei Yao, Nandini Kishore, Irfan Rahman

Pulm Pharmacol Ther. 2010 Jun;23(3):172-81.

PMID: 20080200

1

Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation

Chao-Yang Lai, Yu-Wen Su, Kuo-I Lin, Li-Chung Hsu, Tsung-Hsien Chuang

J Immunol Res. 2017;2017:7807313.

PMID: 28894754

1

Pre-clinical Blocking of PD-L1 Molecule, Which Expression Is Down Regulated by NF-κB, JAK1/JAK2 and BTK Inhibitors, Induces Regression of Activated B-cell Lymphoma

Christelle Vincent-Fabert, Lilian Roland, Ursula Zimber-Strobl, Jean Feuillard, Nathalie Faumont

Cell Commun Signal. 2019 Aug 5;17(1):89.

PMID: 31382969

1

Toll-like Receptors as Therapeutic Targets for Autoimmune Connective Tissue Diseases

Jing Li, Xiaohui Wang, Fengchun Zhang, Hang Yin

Pharmacol Ther. 2013 Jun;138(3):441-51.

PMID: 23531543

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