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Pifithrin-α

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For Research Use Only | Not For Clinical Use
CATAP63208822
CAS63208-82-2
Structure
MDL NumberMFCD00417851
Molecular Weight367.30
InChI KeyHAGVCKULCLQGRF-UHFFFAOYSA-N
Description≥95% (HPLC), powder
SolubilityDMSO: 20 mg/mL
Assay≥95% (HPLC)
Coloroff-white
Formpowder
Linear FormulaC16H18N2OS·HBr
MP192.1-192.5 °C (lit.)
Size5MG, 10MG
Storage Conditions−20°C
1

Neuroprotective Effects of pifithrin-α Against Traumatic Brain Injury in the Striatum Through Suppression of Neuroinflammation, Oxidative Stress, Autophagy, and Apoptosis

Ya-Ni Huang, Ling-Yu Yang, Nigel H Greig, Yu-Chio Wang, Chien-Cheng Lai, Jia-Yi Wang

Sci Rep. 2018 Feb 5;8(1):2368.

PMID: 29402897

1

P53 Inhibitor pifithrin-α Prevents the Renal Tubular Epithelial Cells Against Injury

Yun-Lin Shen, Lei Sun, Yu-Jie Hu, Hua-Jie Liu, Xin-Yu Kuang, Xiao-Ling Niu, Wen-Yan Huang

Am J Transl Res. 2016 Oct 15;8(10):4040-4053.

PMID: 27829991

1

Pifithrin-α Enhances the Survival of Transplanted Neural Stem Cells in Stroke Rats by Inhibiting p53 Nuclear Translocation

Xu-Hui Lei, Dan Zhao, Yong-Li Li, Xian-Feng Li, Xu Sun, Wen-Zhong Du, Ying Sun, Zhong-Fei Hao, Shi-Yue Xin, Cong Liu, Zhi-Ren Zhang, Chuan-Lu Jiang

CNS Neurosci Ther. 2013 Feb;19(2):109-16.

PMID: 23253187

1

Pifithrin-α Provides Neuroprotective Effects at the Level of Mitochondria Independently of p53 Inhibition

Sandra Neitemeier, Goutham K Ganjam, Sebastian Diemert, Carsten Culmsee

Apoptosis. 2014 Dec;19(12):1665-77.

PMID: 25343947

1

Sequential Combined Treatment of Pifithrin-α and Posiphen Enhances Neurogenesis and Functional Recovery After Stroke

Flavia Turcato, Paul Kim, Austin Barnett, Yongming Jin, Mike Scerba, Anthony Casey, Warren Selman, Nigel H Greig, Yu Luo

Cell Transplant. 2018 Apr;27(4):607-621.

PMID: 29871513

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