CAS 916985-21-2 Polo-like Kinase Inhibitor I - Analytical Products / Alfa Chemistry

CAT	AP916985212
CAS	916985-21-2
Molecular Weight	487.55

Description	The Polo-like Kinase Inhibitor I, also referenced under CAS 916985-21-2, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Solubility	DMSO: 10 mg/mL
Assay	≥98% (HPLC)
Color	tan
Form	solid; protect from light
Size	5MG
Storage Conditions	+2C to +8C

1

Current Clinical Trials With Polo-Like Kinase 1 Inhibitors in Solid Tumors

Hyungshin Yim

Anticancer Drugs. 2013 Nov;24(10):999-1006.

PMID: 23949254

1

Phase I Dose Escalation Study of NMS-1286937, an Orally Available Polo-Like Kinase 1 Inhibitor, in Patients With Advanced or Metastatic Solid Tumors

Glen J Weiss, Gayle Jameson, Daniel D Von Hoff, Barbara Valsasina, Cristina Davite, Claudia Di Giulio, Francesco Fiorentini, Rachele Alzani, Patrizia Carpinelli, Alessandro Di Sanzo, Arturo Galvani, Antonella Isacchi, etc.

Invest New Drugs. 2018 Feb;36(1):85-95.

PMID: 28726132

1

Polo-like Kinase Is Required for Synaptonemal Complex Disassembly and Phosphorylation in Mouse Spermatocytes

Philip W Jordan, Jesse Karppinen, Mary A Handel

J Cell Sci. 2012 Nov 1;125(Pt 21):5061-72.

PMID: 22854038

1

Synergistic Induction of Apoptosis by a Polo-Like Kinase 1 Inhibitor and Microtubule-Interfering Drugs in Ewing Sarcoma Cells

Lilly Magdalena Weiß, Manuela Hugle, Sarah Romero, Simone Fulda

Int J Cancer. 2016 Jan 15;138(2):497-506.

PMID: 26260582

1

Vitamin E-Conjugated Phosphopeptide Inhibitor of the Polo-Box Domain of Polo-Like Kinase 1

Min Su Yim, Nak Kyun Soung, Eun Hee Han, Jin-Young Min, HoJin Han, Eun-Ju Son, Hak Nam Kim, BoYeon Kim, Jeong Kyu Bang, Eun Kyoung Ryu

Mol Pharm. 2019 Dec 2;16(12):4867-4877.

PMID: 31663746

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