PPARγ Modulator, SR1664

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For Research Use Only | Not For Clinical Use

CAT	IAR4246435
Molecular Weight	547.60

Description	A cell-permeable non-thiazolidinediones derivative that binds tightly to peroxisome proliferator-activated γ (PPAR-γ) receptor, but does not exhibit any transcriptional agonism.
Solubility	DMSO: 50 mg/mL
Assay	≥92% (HPLC)
Color	red
Form	solid; protect from light
Size	2MG
Storage Conditions	-20C

Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; A Model for Ligand-Dependent Antagonism

Jie Zheng, Cesar Corzo, Mi Ra Chang, Jinsai Shang, Vinh Q Lam, Richard Brust, Anne-Laure Blayo, John B Bruning, Theodore M Kamenecka, Douglas J Kojetin, Patrick R Griffin

Structure. 2018 Nov 6;26(11):1431-1439.e6.

PMID: 30146169

Flightless-1, a Novel Transcriptional Modulator of PPARγ Through Competing With RXRα

Jin Sil Choi, Sun-Sil Choi, Eun Sun Kim, Young-Kyo Seo, Jeong Kon Seo, Eung-Kyun Kim, Pann-Ghill Suh, Jang Hyun Choi

Cell Signal. 2015 Mar;27(3):614-20.

PMID: 25479590

Identification of a Novel Selective PPARγ Ligand With a Unique Binding Mode and Improved Therapeutic Profile in Vitro

Wei Yi, Jingjing Shi, Guanguan Zhao, X Edward Zhou, Kelly Suino-Powell, Karsten Melcher, H Eric Xu

Sci Rep. 2017 Jan 27;7:41487.

PMID: 28128331

Unique Interactome Network Signatures for Peroxisome Proliferator-activated Receptor Gamma (PPARγ) Modulation by Functional Selective Ligands

Vinh Q Lam, Jie Zheng, Patrick R Griffin

Mol Cell Proteomics. 2017 Dec;16(12):2098-2110.

PMID: 28972081

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