0

PR-619

INQUIRY Add to cart
For Research Use Only | Not For Clinical Use
CATAP2645321
CAS2645-32-1
Structure
MDL NumberMFCD00830384
Molecular Weight223.28
InChI KeyZXOBLNBVNROVLC-UHFFFAOYSA-N
Description≥95% (HPLC)
SolubilityDMSO: 5 mg/mL (clear solution)
Assay≥95% (HPLC)
Colorwhite to beige
Formpowder
Size1MG, 5MG
Storage Conditions−20°C
1

Deubiquitinase Inhibitor PR-619 Reduces Smad4 Expression and Suppresses Renal Fibrosis in Mice With Unilateral Ureteral Obstruction

Kotaro Soji, Shigehiro Doi, Ayumu Nakashima, Kensuke Sasaki, Toshiki Doi, Takao Masaki

PLoS One. 2018 Aug 16;13(8):e0202409.

PMID: 30114247

1

Inhibition of Protein Deubiquitination by PR-619 Activates the Autophagic Pathway in OLN-t40 Oligodendroglial Cells

Veronika Seiberlich, Janika Borchert, Victoria Zhukareva, Christiane Richter-Landsberg

Cell Biochem Biophys. 2013 Sep;67(1):149-60.

PMID: 23686611

1

The Deubiquitinating Enzyme Inhibitor PR-619 Enhances the Cytotoxicity of Cisplatin via the Suppression of Anti-Apoptotic Bcl-2 Protein: In Vitro and In Vivo Study

Kuan-Lin Kuo, Shing-Hwa Liu, Wei-Chou Lin, Po-Ming Chow, Yu-Wei Chang, Shao-Ping Yang, Chung-Sheng Shi, Chen-Hsun Hsu, Shih-Ming Liao, Hong-Chiang Chang, Kuo-How Huang

Cells. 2019 Oct 17;8(10):1268.

PMID: 31627336

1

The Deubiquitinating Enzyme Inhibitor PR-619 Is a Potent DNA Topoisomerase II Poison

Ian G Cowell, Elise M Ling, Rebecca L Swan, Matilda L W Brooks, Caroline A Austin

Mol Pharmacol. 2019 Nov;96(5):562-572.

PMID: 31515282

1

The Small Molecule Inhibitor PR-619 of Deubiquitinating Enzymes Affects the Microtubule Network and Causes Protein Aggregate Formation in Neural Cells: Implications for Neurodegenerative Diseases

Veronika Seiberlich, Olaf Goldbaum, Victoria Zhukareva, Christiane Richter-Landsberg

Biochim Biophys Acta. 2012 Nov;1823(11):2057-68.

PMID: 22565157

  • Verification code
Contact Us

Send Us a Request

What is your specific need? We will do everything we can to meet your expectations.
Online Inquiry

Inquiry

For any inquiry, question or recommendation, please call: or fill out the following form.

  • Verification code

Head Office

  • Tel:
  • Email:

Follow us on

qrcode