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PSNCBAM-1

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For Research Use Only | Not For Clinical Use
CATAP877202749
CAS877202-74-9
Structure
MDL NumberMFCD12756395
Molecular Weight392.88
InChI KeyHDAYFSFWIPRJSO-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 15 mg/mL (clear solution)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Effects of the Allosteric Antagonist 1-(4-chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea (PSNCBAM-1) on CB1 Receptor Modulation in the Cerebellum

Xiaowei Wang, James G Horswill, Benjamin J Whalley, Gary J Stephens

Mol Pharmacol. 2011 Apr;79(4):758-67.

PMID: 21189269

1

Novel Analogs of PSNCBAM-1 as Allosteric Modulators of Cannabinoid CB1 Receptor

Simone Bertini, Andrea Chicca, Francesca Gado, Chiara Arena, Daniela Nieri, Maria Digiacomo, Giuseppe Saccomanni, Pingwei Zhao, Mary E Abood, Marco Macchia, Jürg Gertsch, Clementina Manera

Bioorg Med Chem. 2017 Dec 15;25(24):6427-6434.

PMID: 29079014

1

PSNCBAM-1, a Novel Allosteric Antagonist at Cannabinoid CB1 Receptors With Hypophagic Effects in Rats

J G Horswill, U Bali, S Shaaban, J F Keily, P Jeevaratnam, A J Babbs, C Reynet, P Wong Kai In

Br J Pharmacol. 2007 Nov;152(5):805-14.

PMID: 17592509

1

Structural Optimization of the Diarylurea PSNCBAM-1, an Allosteric Modulator of Cannabinoid Receptor 1

Rachel Dopart, Sri Sujana Immadi, Dai Lu, Debra A Kendall

Curr Ther Res Clin Exp. 2019 Dec 24;92:100574.

PMID: 32021660

1

The Great Divide: Separation Between in Vitro and in Vivo Effects of PSNCBAM-based CB

Thomas F Gamage, Charlotte E Farquhar, Timothy W Lefever, Brian F Thomas, Thuy Nguyen, Yanan Zhang, Jenny L Wiley

Neuropharmacology. 2017 Oct;125:365-375.

PMID: 28803965

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