Pyr3 - Analytical Products / Alfa Chemistry

CAT	IAR4244457
MDL Number	MFCD00178741
Molecular Weight	456.63
InChI Key	RZHGONNSASQOAY-UHFFFAOYSA-N

Description	≥98% (HPLC)
Solubility	DMSO: 20 mg/mL, clear
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	2-8°C

1

A TRPC3 Blocker, ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (Pyr3), Prevents Stent-Induced Arterial Remodeling

Sarah Koenig, Michaela Schernthaner, Heinrich Maechler, C Oliver Kappe, Toma N Glasnov, Gerald Hoefler, Marlen Braune, Eric Wittchow, Klaus Groschner

J Pharmacol Exp Ther. 2013 Jan;344(1):33-40.

PMID: 23010361

1

Cloning of the PYR3 Gene of Ustilago Maydis and Its Use in DNA Transformation

G R Banks, S Y Taylor

Mol Cell Biol. 1988 Dec;8(12):5417-24.

PMID: 2907604

1

Pyr3 Induces Apoptosis and Inhibits Migration in Human Glioblastoma Cells

Hsin-Han Chang, Yu-Chen Cheng, Wen-Chiuan Tsai, Min-Jen Tsao, Ying Chen

Cell Physiol Biochem. 2018;48(4):1694-1702.

PMID: 30078005

1

Pyr3, a TRPC3 Channel Blocker, Potentiates Dexamethasone Sensitivity and Apoptosis in Acute Lymphoblastic Leukemia Cells by Disturbing Ca(2+) Signaling, Mitochondrial Membrane Potential Changes and Reactive Oxygen Species Production

Souleymane Abdoul-Azize, Catherine Buquet, Jean-Pierre Vannier, Isabelle Dubus

Eur J Pharmacol. 2016 Aug 5;784:90-8.

PMID: 27179991

1

TRP Channels: Their Function and Potentiality as Drug Targets

Motohiro Nishida, Koichiro Kuwahara, Daisuke Kozai, Reiko Sakaguchi, Yasuo Mori, Kazuwa Nakao, Nagahiro Minato, Shinji Uemoto

PMID: 29787169

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