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Quininib

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For Research Use Only | Not For Clinical Use
CATAP143816426
CAS143816-42-6
MDL NumberMFCD00186931
Molecular Weight247.29
InChI KeyNXNDEWNGCMCWMA-ZRDIBKRKSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

1,4-dihydroxy Quininib Attenuates Growth of Colorectal Cancer Cells and Xenografts and Regulates the TIE-2 Signaling Pathway in Patient Tumours

Clare T Butler, Susan A Kennedy, Amy Buckley, Ronan Doyle, Emer Conroy, William M Gallagher, Jacintha O'Sullivan, Breandán N Kennedy

Oncotarget. 2019 Jun 4;10(38):3725-3744.

PMID: 31217905

1

A Quininib Analogue and Cysteinyl Leukotriene Receptor Antagonist Inhibits Vascular Endothelial Growth Factor (VEGF)-independent Angiogenesis and Exerts an Additive Antiangiogenic Response With Bevacizumab

Clare T Butler, Alison L Reynolds, Miriam Tosetto, Eugene T Dillon, Patrick J Guiry, Gerard Cagney, Jacintha O'Sullivan, Breandán N Kennedy

J Biol Chem. 2017 Mar 3;292(9):3552-3567.

PMID: 28035003

1

A Sustained Release Formulation of Novel Quininib-Hyaluronan Microneedles Inhibits Angiogenesis and Retinal Vascular Permeability in Vivo

Orla Galvin, Akshay Srivastava, Oliver Carroll, Rajiv Kulkarni, Steve Dykes, Steven Vickers, Keith Dickinson, Alison L Reynolds, Claire Kilty, Gareth Redmond, Rob Jones, Sharon Cheetham, Abhay Pandit, Breandán N Kennedy

J Control Release. 2016 Jul 10;233:198-207.

PMID: 27086168

1

Phenotype-based Discovery of 2-[(E)-2-(Quinolin-2-yl)vinyl]phenol as a Novel Regulator of Ocular Angiogenesis

Alison L Reynolds, Yolanda Alvarez, Temitope Sasore, Nora Waghorne, Clare T Butler, Claire Kilty, Andrew J Smith, Carmel McVicar, Vickie H Y Wong, Orla Galvin, Stephanie Merrigan, Janina Osman, Gleb Grebnev, etc.

J Biol Chem. 2016 Apr 1;291(14):7242-55.

PMID: 26846851

1

Preclinical Validation of the Small Molecule Drug Quininib as a Novel Therapeutic for Colorectal Cancer

Adrian G Murphy, Rory Casey, Aoife Maguire, Miriam Tosetto, Clare T Butler, Emer Conroy, Alison L Reynolds, Kieran Sheahan, Diarmuid O'Donoghue, William M Gallagher, David Fennelly, Breandán N Kennedy, etc.

Sci Rep. 2016 Oct 14;6:34523.

PMID: 27739445

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