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R-7050

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For Research Use Only | Not For Clinical Use
CATAP303997355
CAS303997-35-5
MDL NumberMFCD00140737
Molecular Weight380.77
InChI KeySUUMKHOVGVYGOP-UHFFFAOYSA-N
Description≥95% (HPLC)
SolubilityDMSO: 2 mg/mL, clear (warmed)
Assay≥95% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

Adipose Afferent Reflex Is Enhanced by TNFα in Paraventricular Nucleus Through NADPH Oxidase-Dependent ROS Generation in Obesity-Related Hypertensive Rats

Lei Ding, Ying Kang, Hang-Bing Dai, Fang-Zheng Wang, Hong Zhou, Qing Gao, Xiao-Qing Xiong, Feng Zhang, Tian-Run Song, Yan Yuan, Ming Liu, Guo-Qing Zhu, Ye-Bo Zhou

J Transl Med. 2019 Aug 7;17(1):256.

PMID: 31391086

1

Hyperoxaluria Requires TNF Receptors to Initiate Crystal Adhesion and Kidney Stone Disease

Shrikant R Mulay, Jonathan N Eberhard, Jyaysi Desai, Julian A Marschner, Santhosh V R Kumar, Marc Weidenbusch, Melissa Grigorescu, Maciej Lech, Nuru Eltrich, Lisa Müller, Wolfgang Hans, Martin Hrabě de Angelis, etc.

J Am Soc Nephrol. 2017 Mar;28(3):761-768.

PMID: 27612997

1

KLF4 in Macrophages Attenuates TNF α-Mediated Kidney Injury and Fibrosis

Yi Wen, Xiaohan Lu, Jiafa Ren, Jamie R Privratsky, Bo Yang, Nathan P Rudemiller, Jiandong Zhang, Robert Griffiths, Mukesh K Jain, Sergei A Nedospasov, Bi Cheng Liu, Steven D Crowley

J Am Soc Nephrol. 2019 Oct;30(10):1925-1938.

PMID: 31337692

1

TNF-alpha Receptor Antagonist, R-7050, Improves Neurological Outcomes Following Intracerebral Hemorrhage in Mice

Melanie D King, Cargill H Alleyne Jr, Krishnan M Dhandapani

Neurosci Lett. 2013 May 10;542:92-6.

PMID: 23499961

1

Tumor Necrosis Factor Alpha Has a Crucial Role in Increased Reactive Oxygen Species Production in Platelets of Mice Injected With Lipopolysaccharide

Ana C Antunes Naime, Pedro H L Bonfitto, Carolina Solon, Maria Elisa Lopes-Pires, Gabriel F Anhê, Edson Antunes, Sisi Marcondes

Platelets. 2019;30(8):1047-1052.

PMID: 31076004

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