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R(+)-HA-966

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For Research Use Only | Not For Clinical Use
CATAP123931044
CAS123931-04-4
Structure
MDL NumberMFCD00078583
Molecular Weight116.12
InChI KeyHCKUBNLZMKAEIN-GSVOUGTGSA-N
Descriptionsolid
SolubilityH2O: soluble
Colorwhite
Formsolid
Size5MG
1

(S)-(-)-HA-966, a Gamma-Hydroxybutyrate-Like Agent, Prevents Enhanced Mesocorticolimbic Dopamine Metabolism and Behavioral Correlates of Restraint Stress, Conditioned Fear and Cocaine Sensitization

B A Morrow, E J Lee, J R Taylor, J D Elsworth, H E Nye, R H Roth

J Pharmacol Exp Ther. 1997 Nov;283(2):712-21.

PMID: 9353390

1

Biochemical and Behavioral Anxiolytic-Like Effects of R(+)HA-966 at the Level of the Ventral Tegmental Area in Rats

B A Morrow, J D Elsworth, C Zito, R H Roth

Psychopharmacology (Berl). 1999 Apr;143(3):227-34.

PMID: 10353424

1

Stereoselective R-(+) Enantiomer of HA-966 Displays Anxiolytic Effects in Rodents

R W Dunn, D M Flanagan, L L Martin, L L Kerman, A T Woods, F Camacho, C A Wilmot, M L Cornfeldt, R C Effland, P L Wood

Eur J Pharmacol. 1992 Apr 22;214(2-3):207-14.

PMID: 1355434

1

Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the Glycine Site of the N-methyl-D-aspartate Receptor Complex

L M Pullan, M Britt, M J Chapdelaine, R A Keith, D LaMonte, T J Mangano, J Patel, R J Powel, R J Stumpo, P J Warwick

J Neurochem. 1990 Oct;55(4):1346-51.

PMID: 1975835

1

The glycine/NMDA Receptor Antagonist, R-(+)-HA-966, Blocks Activation of the Mesolimbic Dopaminergic System Induced by Phencyclidine and Dizocilpine (MK-801) in Rodents

L J Bristow, P H Hutson, L Thorn, M D Tricklebank

Br J Pharmacol. 1993 Apr;108(4):1156-63.

PMID: 8485625

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