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R547

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For Research Use Only | Not For Clinical Use
CATAP741713406
CAS741713-40-6
Structure
MDL NumberMFCD09970629
Molecular Weight441.45
InChI KeyJRNJNYBQQYBCLE-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 5 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Cyclin-dependent Kinase Inhibitors AZD5438 and R547 Show Potential for Enhancing Efficacy of Daunorubicin-Based Anticancer Therapy: Interaction With Carbonyl-Reducing Enzymes and ABC Transporters

Ales Sorf, Eva Novotna, Jakub Hofman, Anselm Morell, Frantisek Staud, Vladimir Wsol, Martina Ceckova

Biochem Pharmacol. 2019 May;163:290-298.

PMID: 30826329

1

Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- Methoxyphenyl)methanone (R547), a Potent and Selective Cyclin-Dependent Kinase Inhibitor With Significant in Vivo Antitumor Activity

Xin-Jie Chu, Wanda DePinto, David Bartkovitz, Sung-Sau So, Binh T Vu, Kathryn Packman, Christine Lukacs, Qingjie Ding, Nan Jiang, Ka Wang, Petra Goelzer, Xuefeng Yin, Melissa A Smith, Brian X Higgins, Yingsi Chen, etc.

J Med Chem. 2006 Nov 2;49(22):6549-60.

PMID: 17064073

1

In Vitro and in Vivo Activity of R547: A Potent and Selective Cyclin-Dependent Kinase Inhibitor Currently in Phase I Clinical Trials

Wanda DePinto, Xin-Jie Chu, Xuefeng Yin, Melissa Smith, Kathryn Packman, Petra Goelzer, Allen Lovey, Yingsi Chen, Hong Qian, Rachid Hamid, Qing Xiang, Christian Tovar, Roger Blain, Tom Nevins, Brian Higgins, etc.

Mol Cancer Ther. 2006 Nov;5(11):2644-58.

PMID: 17121911

1

Preclinical Biomarkers for a Cyclin-Dependent Kinase Inhibitor Translate to Candidate Pharmacodynamic Biomarkers in Phase I Patients

Windy Berkofsky-Fessler, Tri Q Nguyen, Paul Delmar, Juliette Molnos, Charu Kanwal, Wanda DePinto, James Rosinski, Patricia McLoughlin, Steve Ritland, Mark DeMario, Krishna Tobon, John F Reidhaar-Olson, etc.

Mol Cancer Ther. 2009 Sep;8(9):2517-25.

PMID: 19755512

1

Targeted Transferrin-Modified Polymeric Micelles: Enhanced Efficacy in Vitro and in Vivo in Ovarian Carcinoma

Rupa R Sawant, Aditi M Jhaveri, Alexander Koshkaryev, Lin Zhu, Farooq Qureshi, Vladimir P Torchilin

Mol Pharm. 2014 Feb 3;11(2):375-81.

PMID: 24325630

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