RAGE Antagonist, FPS-ZM1 - Analytical Products / Alfa Chemistry

CAT	IAR4249409
Molecular Weight	327.85

Description	RAGE Antagonist, FPS-ZM1, is a blood-brain-barrier permeant blocker of RAGE V domain-mediated ligand binding (Ki = 25, 148, & 230 nM, respectively, against Aβ40, HMGB1 & S100B, binding to sRAGE).
Solubility	DMSO: 100 mg/mL
Assay	≥98% (HPLC)
Color	white to off-white
Form	semisolid; viscous liquid; protect from light
Size	25MG
Storage Conditions	+2C to +8C

1

Activation of the RAGE/STAT3 Pathway in the Dorsal Root Ganglion Contributes to the Persistent Pain Hypersensitivity Induced by Lumbar Disc Herniation

Xin-Sheng Zhang, Xiao Li, Hai-Jie Luo, Zhu-Xi Huang, Cui-Cui Liu, Qing Wan, Shu-Wei Xu, Shao-Ling Wu, Song-Jian Ke, Chao Ma

Pain Physician. 2017 Jul;20(5):419-427.

PMID: 28727705

1

Blockade of RAGE Ameliorates Elastase-Induced Emphysema Development and Progression

Hanbyeol Lee, Jeong-Ran Park, Woo Jin Kim, Isaac K Sundar, Irfan Rahman, Sung-Min Park, Se-Ran Yang

FASEB J. 2017 May;31(5):2076-2089.

PMID: 28148566

1

Glucocorticoids Decrease the Numbers and Activation of Mast Cells by Inducing the Transactivation Receptors of AGEs

Tassia Santoro, Carolina T Azevedo, Patrícia M R E Silva, Marco A Martins, Vinicius F Carvalho

J Leukoc Biol. 2019 Jan;105(1):131-142.

PMID: 30199117

1

High-Mobility Group Box 1 Is Associated With the Inflammatory Pathogenesis of Graves' Orbitopathy

So Young Han, Soo Hyun Choi, Jeon-Soo Shin, Eun Jig Lee, Sueng-Han Han, Jin Sook Yoon

Thyroid. 2019 Jun;29(6):868-878.

PMID: 30973094

1

Impaired Oligodendrogenesis and Myelination by Elevated S100B Levels During Neurodevelopment

Gisela Santos, Andreia Barateiro, Cláudio M Gomes, Dora Brites, Adelaide Fernandes

Neuropharmacology. 2018 Feb;129:69-83.

PMID: 29126910

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