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Rb/Raf-1 Disruptor 251

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For Research Use Only | Not For Clinical Use
CATAP72214676
CAS72214-67-6
Molecular Weight271.59
DescriptionA cell-permeable and orally active isothiouronium compound that potently and selectively disrupts the Rb/Raf-1 interaction, while exhibiting no effect against Rb/B-Raf, Rb/E2F1, Rb/HDAC1, Raf-1/MEK1.
Solubilityethanol: 20 mg/mL; DMSO: 50 mg/mL
Assay≥97% (HPLC)
Colorwhite
Formsolid; desiccated; protect from light
Size25MG
Storage Conditions+2C to +8C
1

A Small Molecule Disruptor of Rb/Raf-1 Interaction Inhibits Cell Proliferation, Angiogenesis, and Growth of Human Tumor Xenografts in Nude Mice

Rebecca Kinkade, Piyali Dasgupta, Adam Carie, Daniele Pernazza, Melanie Carless, Smitha Pillai, Nicholas Lawrence, Said M Sebti, Srikumar Chellappan

Cancer Res. 2008 May 15;68(10):3810-8.

PMID: 18483265

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Disrupting the Rb-Raf-1 Interaction: A Potential Therapeutic Target for Cancer

Rebecca K Davis, Srikumar Chellappan

Drug News Perspect. Jul-Aug 2008;21(6):331-5.

PMID: 18836591

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