REV-ERBα Agonist, GSK4112

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For Research Use Only | Not For Clinical Use

CAT	IAR4249366
Molecular Weight	396.89

Description	The REV-ERBα Agonist, GSK4112 controls the biological activity of REV-ERBα. This small molecule/inhibitor is primarily used for Biochemicals applications.
Solubility	DMSO: 50 mg/mL
Assay	≥95% (HPLC)
Color	dark beige
Form	solid; protect from light
Size	10MG
Storage Conditions	-20C

Pharmacological Activation of REV-ERBα Represses LPS-induced Microglial Activation Through the NF-κB Pathway

Dong-Kai Guo, Yao Zhu, Hong-Yang Sun, Xing-Yun Xu, Shun Zhang, Zong-Bing Hao, Guang-Hui Wang, Chen-Chen Mu, Hai-Gang Ren

Acta Pharmacol Sin. 2019 Jan;40(1):26-34.

PMID: 29950615

Rev-erbα Inhibits Proliferation and Promotes Apoptosis of Preadipocytes Through the Agonist GSK4112

Guiyan Chu, Xiaoge Zhou, Yamei Hu, Shengjie Shi, Gongshe Yang

Int J Mol Sci. 2019 Sep 12;20(18):4524.

PMID: 31547330

Rev-erbα Inhibits Proliferation by Reducing Glycolytic Flux and Pentose Phosphate Pathway in Human Gastric Cancer Cells

Linlin Tao, Haoyuan Yu, Rui Liang, Ru Jia, Jingjing Wang, Kai Jiang, Zhengguang Wang

Oncogenesis. 2019 Oct 7;8(10):57.

PMID: 31591390

Rev-erbα Regulates Circadian Rhythms and StAR Expression in Rat Granulosa Cells as Identified by the Agonist GSK4112

Huatao Chen, Guiyan Chu, Lijia Zhao, Nobuhiko Yamauchi, Yasufumi Shigeyoshi, Seiichi Hashimoto, Masa-aki Hattori

Biochem Biophys Res Commun. 2012 Apr 6;420(2):374-9.

PMID: 22425774

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