Rho Kinase Inhibitor - Analytical Products / Alfa Chemistry

CAT	IAR42415733
Molecular Weight	319.42

Description	The Rho kinase inhibitor, CAS 872543-07-6, is a cell-permeable, highly specific, reversible, potent, and ATP-competitive inhibitor of Rho-associated kinase (ROCK; Ki = 1.6 nM).
Solubility	methanol: 5 mg/mL; water: 5 mg/mL
Assay	≥95% (HPLC)
Color	white
Form	solid; desiccated; protect from light
Size	1MG, 5MG
Storage Conditions	+2C to +8C

1

Protective Effect of Inhaled Rho-Kinase Inhibitor on Lung Ischemia-Reperfusion Injury

Keiji Ohata, Toyofumi F Chen-Yoshikawa, Toshi Menju, Ei Miyamoto, Satona Tanaka, Mamoru Takahashi, Hideki Motoyama, Kyoko Hijiya, Akihiro Aoyama, Hiroshi Date

Ann Thorac Surg. 2017 Feb;103(2):476-483.

PMID: 27743639

1

Rho-kinase Inhibitor Attenuates Airway Mucus Hypersecretion and Inflammation Partly by Downregulation of IL-13 and the JNK1/2-AP1 Signaling Pathway

Wenqin Zhang, Xin Li, Yun Zhang

Biochem Biophys Res Commun. 2019 Aug 20;516(2):571-577.

PMID: 31235256

1

Rho-kinase Inhibitor Y-27632 Attenuates Pulmonary Hypertension in Hyperoxia-Exposed Newborn Rats

Hsiu-Chu Chou, Liang-Ti Huang, Tsu-Fu Yeh, Chung-Ming Chen

Acta Pharmacol Sin. 2013 Oct;34(10):1310-6.

PMID: 23974518

1

Rho-kinase Inhibitor Y-27632 Downregulates LPS-induced IL-6 and IL-8 Production via Blocking p38 MAPK and NF-κB Pathways in Human Gingival Fibroblasts

Wenyan Kang, Lingling Shang, Ting Wang, Hongrui Liu, Shaohua Ge

J Periodontol. 2018 Jul;89(7):883-893.

PMID: 29630729

1

The Rho kinase inhibitor fasudil attenuates Aβ 1-42-induced apoptosis via the ASK1/JNK signal pathway in primary cultures of hippocampal neurons

Ye Gao, Yuqing Yan, Qingli Fang, Nianping Zhang, Gajendra Kumar, Jihong Zhang, Li-Juan Song, Jiezhong Yu, Linhu Zhao, Han-Ting Zhang, Cun-Gen Ma

Metab Brain Dis. 2019 Dec;34(6):1787-1801.

PMID: 31482248

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