CAS 150627-37-5 RK-682 - Analytical Products / Alfa Chemistry

CAT	AP150627375
CAS	150627-37-5
MDL Number	MFCD20488046
Molecular Weight	368.51
InChI Key	KZTSLHQKWLYYAC-GOSISDBHSA-N

Description	≥98% (HPLC)
Solubility	DMSO, heptane and xylene: ≥8 mg/mL
Assay	≥98% (HPLC)
Color	white to tan
Form	powder
Size	200μG, 1MG
Storage Conditions	−20°C

1

Design and Synthesis of a Dimeric Derivative of RK-682 With Increased Inhibitory Activity Against VHR, a Dual-Specificity ERK Phosphatase: Implications for the Molecular Mechanism of the Inhibition

T Usui, S Kojima, S Kidokoro, K Ueda, H Osada, M Sodeoka

Chem Biol. 2001 Dec;8(12):1209-20.

PMID: 11755399

1

In Vitro Reconstruction of Tetronate RK-682 Biosynthesis

Yuhui Sun, Frank Hahn, Yuliya Demydchuk, James Chettle, Manuela Tosin, Hiroyuki Osada, Peter F Leadlay

Nat Chem Biol. 2010 Feb;6(2):99-101.

PMID: 20081823

1

Is RK-682 a Promiscuous Enzyme Inhibitor? Synthesis and in Vitro Evaluation of Protein Tyrosine Phosphatase Inhibition of Racemic RK-682 and Analogues

Vânia M T Carneiro, Daniela B B Trivella, Valéria Scorsato, Viviane L Beraldo, Mariana P Dias, Tiago J P Sobreira, Ricardo Aparicio, Ronaldo A Pilli

Eur J Med Chem. 2015 Jun 5;97:42-54.

PMID: 25938987

1

RK-682, a Potent Inhibitor of Tyrosine Phosphatase, Arrested the Mammalian Cell Cycle Progression at G1phase

T Hamaguchi, T Sudo, H Osada

FEBS Lett. 1995 Sep 18;372(1):54-8.

PMID: 7556642

1

Structure-based Design of a Selective Heparanase Inhibitor as an Antimetastatic Agent

Keisuke Ishida, Go Hirai, Koji Murakami, Takayuki Teruya, Siro Simizu, Mikiko Sodeoka, Hiroyuki Osada

Mol Cancer Ther. 2004 Sep;3(9):1069-77.

PMID: 15367701

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