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RO3280

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For Research Use Only | Not For Clinical Use
CATAP1062243519
CAS1062243-51-9
MDL NumberMFCD22665717
Molecular Weight543.61
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

Identification of Novel, Potent and Selective Inhibitors of Polo-like Kinase 1

Shaoqing Chen, David Bartkovitz, Jianping Cai, Yi Chen, Zhi Chen, Xin-Jie Chu, Kang Le, Nam T Le, Kin-Chun Luk, Steve Mischke, Goli Naderi-Oboodi, John F Boylan, Tom Nevins, Weiguo Qing, Yingsi Chen, Peter M Wovkulich

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1247-50.

PMID: 22172702

1

Inhibiting PLK1 Induces Autophagy of Acute Myeloid Leukemia Cells via Mammalian Target of Rapamycin Pathway Dephosphorylation

Yan-Fang Tao, Zhi-Heng Li, Wei-Wei Du, Li-Xiao Xu, Jun-Li Ren, Xiao-Lu Li, Fang Fang, Yi Xie, Mei Li, Guang-Hui Qian, Yan-Hong Li, Yi-Ping Li, Gang Li, Yi Wu, Xing Feng, Jian Wang, Wei-Qi He, Shao-Yan Hu, etc.

Oncol Rep. 2017 Mar;37(3):1419-1429.

PMID: 28184925

1

Molecular Targeting of the Oncoprotein PLK1 in Pediatric Acute Myeloid Leukemia: RO3280, a Novel PLK1 Inhibitor, Induces Apoptosis in Leukemia Cells

Na-Na Wang, Zhi-Heng Li, He Zhao, Yan-Fang Tao, Li-Xiao Xu, Jun Lu, Lan Cao, Xiao-Juan Du, Li-Chao Sun, Wen-Li Zhao, Pei-Fang Xiao, Fang Fang, Guang-Hao Su, Yan-Hong Li, Gang Li, Yi-Ping Li, Yun-Yun Xu, etc.

Int J Mol Sci. 2015 Jan 7;16(1):1266-92.

PMID: 25574601

1

RO3280: A Novel PLK1 Inhibitor, Suppressed the Proliferation of MCF-7 Breast Cancer Cells Through the Induction of Cell Cycle Arrest at G2/M Point

Mustafa Ergul, Filiz Bakar-Ates

Anticancer Agents Med Chem. 2019;19(15):1846-1854.

PMID: 31244432

1

Targeted Inhibition of Polo-like Kinase 1 by a Novel Small-Molecule Inhibitor Induces Mitotic Catastrophe and Apoptosis in Human Bladder Cancer Cells

Zhe Zhang, Guojun Zhang, Chuize Kong

J Cell Mol Med. 2017 Apr;21(4):758-767.

PMID: 27878946

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