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Ru360

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For Research Use Only | Not For Clinical Use
CATIAR4249119
Molecular Weight550.78
DescriptionRu360, is a cell-permeable oxygen-bridged dinuclear ruthenium amine complex. Binds to mitochondria with high affinity (Kd = 340 pM) and blocks Ca2+ uptake into mitochondria in vitro (IC₅₀ = 184 pM).
Solubilitydeoxygenated water: 0.5 mg/mL
Assay≥97% (capillary electrophoresis)
Colorgreen
Formsolid; desiccated; protect from light
Size500μG, 1SET
Storage Conditions-20C
1

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics After Hypoxia/Reoxygenation Injury

Joshua J Woods, Neeharika Nemani, Santhanam Shanmughapriya, Akshay Kumar, MengQi Zhang, Sarah R Nathan, Manfred Thomas, Edmund Carvalho, Karthik Ramachandran, Subramanya Srikantan, Peter B Stathopulos, etc.

ACS Cent Sci. 2019 Jan 23;5(1):153-166.

PMID: 30693334

1

Architecture of the Mitochondrial Calcium Uniporter

Kirill Oxenoid, Ying Dong, Chan Cao, Tanxing Cui, Yasemin Sancak, Andrew L Markhard, Zenon Grabarek, Liangliang Kong, Zhijun Liu, Bo Ouyang, Yao Cong, Vamsi K Mootha, James J Chou

Nature. 2016 May 12;533(7602):269-73.

PMID: 27135929

1

MCU Up-regulation Contributes to Myocardial Ischemia-Reperfusion Injury Through calpain/OPA-1-mediated Mitochondrial fusion/mitophagy Inhibition

Lichun Guan, Zhimei Che, Xiangdong Meng, Yong Yu, Minghui Li, Ziqin Yu, Hui Shi, Dicheng Yang, Min Yu

J Cell Mol Med. 2019 Nov;23(11):7830-7843.

PMID: 31502361

1

MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca 2+ Flux and Sensitivity to Ru360

Melanie Paillard, György Csordás, Kai-Ting Huang, Peter Várnai, Suresh K Joseph, György Hajnóczky

Mol Cell. 2018 Nov 15;72(4):778-785.e3.

PMID: 30454562

1

UCP2 Modulates Cardioprotective Effects of Ru360 in Isolated Cardiomyocytes During Ischemia

Lukas J Motloch, Sara Reda, Martin Wolny, Uta C Hoppe

Pharmaceuticals (Basel). 2015 Aug 4;8(3):474-82.

PMID: 26248074

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