CAS 142872-84-2 RX871024 - Analytical Products / Alfa Chemistry

CAT	AP142872842
CAS	142872-84-2
Molecular Weight	297.78

Description	≥98% (HPLC)
Solubility	H2O: 15 mg/mL, clear
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	2-8°C

1

Different Modes of Action of the Imidazoline Compound RX871024 in Pancreatic Beta-Cells. Blocking of K+ Channels, Mobilization of Ca2+ From Endoplasmic Reticulum, and Interaction With Exocytotic Machinery

S V Zaitsev, A M Efanov, A Raap, I B Efanova, J Schloos, B Steckel-Hamann, O Larsson, C G Ostenson, P O Berggren, H J Mest, S Efendic

Ann N Y Acad Sci. 1999 Jun 21;881:241-52.

PMID: 10415922

1

Insulinotropic Activity of the Imidazoline Derivative RX871024 in the Diabetic GK Rat

Alexander M Efanov, Ioulia B Appelskog, Samy M Abdel-Halim, Akhtar Khan, Robert Bränström, Olof Larsson, Claes-Göran Ostenson, Hans-Juergen Mest, Per-Olof Berggren, Suad Efendic, Sergei V Zaitsev

Am J Physiol Endocrinol Metab. 2002 Jan;282(1):E117-24.

PMID: 11739091

1

RX871024 Reduces NO Production but Does Not Protect Against Pancreatic Beta-Cell Death Induced by Proinflammatory Cytokines

Irina I Zaitseva, Vladimir Sharoyko, Joachim Størling, Suad Efendic, Christopher Guerin, Thomas Mandrup-Poulsen, Pierluigi Nicotera, Per-Olof Berggren, Sergei V Zaitsev

Biochem Biophys Res Commun. 2006 Sep 8;347(4):1121-8.

PMID: 16870144

1

Selective Enhancement of Nutrient-Induced Insulin Secretion by ATP-sensitive K+ Channel-Blocking Imidazolines

Kathrin Hatlapatka, Antje Wienbergen, Claudia Kühne, Anne Jörns, Michael Willenborg, Ingo Rustenbeck

J Pharmacol Exp Ther. 2009 Dec;331(3):1033-41.

PMID: 19745109

1

The Imidazoline Compound RX871024 Promotes Insulinoma Cell Death Independent of AMP-activated Protein Kinase Inhibition

Irina I Zaitseva, Sergei V Zaitsev, Per-Olof Berggren

Invest New Drugs. 2016 Aug;34(4):522-9.

PMID: 27221730

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