CAS 1374356-45-2 (S)-Crizotinib - Analytical Products / Alfa Chemistry

CAT	AP1374356452
CAS	1374356-45-2
MDL Number	MFCD22126092
Molecular Weight	450.34
InChI Key	KTEIFNKAUNYNJU-LBPRGKRZSA-N

Description	≥98% (HPLC)
Solubility	DMSO: 5 mg/mL, clear (warmed)
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG
Storage Conditions	room temp

1

(S)-crizotinib Induces Apoptosis in Human Non-Small Cell Lung Cancer Cells by Activating ROS Independent of MTH1

Xuanxuan Dai, Guilong Guo, Peng Zou, Ri Cui, Weiqian Chen, Xi Chen, Changtian Yin, Wei He, Rajamanickam Vinothkumar, Fan Yang, Xiaohua Zhang, Guang Liang

J Exp Clin Cancer Res. 2017 Sep 7;36(1):120.

PMID: 28882182

1

(S)-crizotinib Reduces Gastric Cancer Growth Through Oxidative DNA Damage and Triggers Pro-Survival Akt Signal

Jiansong Ji, Weiqian Chen, Weishuai Lian, Ruijie Chen, Jinqing Yang, Qianqian Zhang, Qiaoyou Weng, Zia Khan, Jie Hu, Xi Chen, Peng Zou, Xiaoming Chen, Guang Liang

Cell Death Dis. 2018 May 31;9(6):660.

PMID: 29855474

1

Anticancer Effect of (S)-crizotinib on Osteosarcoma Cells by Targeting MTH1 and Activating Reactive Oxygen Species

Xiangcheng Qing, Zengwu Shao, Xiao Lv, Feifei Pu, Feng Gao, Lei Liu, Deyao Shi

Anticancer Drugs. 2018 Apr;29(4):341-352.

PMID: 29420337

1

Proteome-wide Drug and Metabolite Interaction Mapping by Thermal-Stability Profiling

Kilian V M Huber, Karin M Olek, André C Müller, Chris Soon Heng Tan, Keiryn L Bennett, Jacques Colinge, Giulio Superti-Furga

Nat Methods. 2015 Nov;12(11):1055-7.

PMID: 26389571

1

Stereospecific Targeting of MTH1 by (S)-crizotinib as an Anticancer Strategy

Kilian V M Huber, Eidarus Salah, Branka Radic, Manuela Gridling, Jonathan M Elkins, Alexey Stukalov, Ann-Sofie Jemth, Camilla Göktürk, Kumar Sanjiv, Kia Strömberg, Therese Pham, Ulrika Warpman Berglund, etc.

Nature. 2014 Apr 10;508(7495):222-7.

PMID: 24695225

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