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(S)-PFI-2

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For Research Use Only | Not For Clinical Use
CATAP1627607888
CAS1627607-88-8
Molecular Weight535.98
InChI KeyZADKZNVAJGEFLC-BOXHHOBZSA-N
SolubilityH2O: 2 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

(R)-PFI-2 Is a Potent and Selective Inhibitor of SETD7 Methyltransferase Activity in Cells

Dalia Barsyte-Lovejoy, Fengling Li, Menno J Oudhoff, John H Tatlock, Aiping Dong, Hong Zeng, Hong Wu, Spencer A Freeman, Matthieu Schapira, Guillermo A Senisterra, Ekaterina Kuznetsova, Richard Marcellus, etc.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12853-8.

PMID: 25136132

1

Revealing Inhibition Difference Between PFI-2 Enantiomers Against SETD7 by Molecular Dynamics Simulations, Binding Free Energy Calculations and Unbinding Pathway Analysis

Yuzhen Niu, Danfeng Shi, Lanlan Li, Jingyun Guo, Huanxiang Liu, Xiaojun Yao

Sci Rep. 2017 Apr 18;7:46547.

PMID: 28417976

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