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(S)-SNAP-5114

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For Research Use Only | Not For Clinical Use
CATAP157604552
CAS157604-55-2
Structure
MDL NumberMFCD06411702
Molecular Weight505.60
InChI KeyVDLDUZLDZBVOAS-QFIPXVFZSA-N
Description≥98% (HPLC), solid
SolubilityDMSO: >5 mg/mL; H2O: insoluble
Assay≥98% (HPLC)
Colorwhite
Formsolid
Size5MG, 25MG
Storage Conditions−20°C
1

Development of an (S)-1-{2-[tris(4-methoxyphenyl)methoxy]ethyl}piperidine-3-carboxylic Acid [(S)-SNAP-5114] Carba Analogue Inhibitor for Murine γ-aminobutyric Acid Transporter Type 4

Jörg Pabel, Mark Faust, Cornelia Prehn, Babette Wörlein, Lars Allmendinger, Georg Höfner, Klaus T Wanner

ChemMedChem. 2012 Jul;7(7):1245-55.

PMID: 22544452

1

Inhibition of GABA Transporters Fails to Afford Significant Protection Following Focal Cerebral Ischemia

Maria Ek Lie, Emma K Gowing, Rasmus P Clausen, Petrine Wellendorph, Andrew N Clarkson

J Cereb Blood Flow Metab. 2018 Jan;38(1):166-173.

PMID: 29148909

1

N-Substituted Nipecotic Acids as (S)-SNAP-5114 Analogues With Modified Lipophilic Domains

Michael C Böck, Georg Höfner, Klaus T Wanner

ChemMedChem. 2020 May 6;15(9):756-771.

PMID: 32187815

1

Synthesis and Biological Evaluation of Novel N-substituted Nipecotic Acid Derivatives With a Trans-Alkene Spacer as Potent GABA Uptake Inhibitors

Krisztián Tóth, Georg Höfner, Klaus T Wanner

Bioorg Med Chem. 2018 Dec 1;26(22):5944-5961.

PMID: 30442505

1

Synthesis and Biological Evaluation of Novel N-substituted Nipecotic Acid Derivatives With an Alkyne Spacer as GABA Uptake Inhibitors

Krisztián Tóth, Georg Höfner, Klaus T Wanner

Bioorg Med Chem. 2018 Jul 23;26(12):3668-3687.

PMID: 29886082

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