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S14161

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For Research Use Only | Not For Clinical Use
CATAP883046502
CAS883046-50-2
MDL NumberMFCD00112055
Molecular Weight315.30
InChI KeyBFZXDHIUPNWOMT-UHFFFAOYSA-N
Description≥98% (HPLC)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder; protect from light
Size1MG, 5MG
Storage Conditions−20°C
1

A Small-Molecule Inhibitor of D-cyclin Transactivation Displays Preclinical Efficacy in Myeloma and Leukemia via Phosphoinositide 3-kinase Pathway

Xinliang Mao, Biyin Cao, Tabitha E Wood, Rose Hurren, Jiefei Tong, Xiaoming Wang, Wenjie Wang, Jie Li, Yueping Jin, Wenxian Sun, Paul A Spagnuolo, Neil MacLean, Michael F Moran, Alessandro Datti, Jeffery Wrana, etc.

Blood. 2011 Feb 10;117(6):1986-97.

PMID: 21135258

1

Effects of BENC-511, a Novel PI3K Inhibitor, on the Proliferation and Apoptosis of A549 Human Lung Adenocarcinoma Cells

Huiqin Tian, Yu Zhang, Qianyun Zhang, Shuixian Li, Yang Liu, Xiuzhen Han

Biosci Trends. 2019;13(1):40-48.

PMID: 30867372

1

Modulation of Platelet Activation and Thrombus Formation Using a pan-PI3K Inhibitor S14161

Wenxiu Yi, Qiang Li, Jian Shen, Lijie Ren, Xiaohui Liu, Qi Wang, Sudan He, Qingyu Wu, Hu Hu, Xinliang Mao, Li Zhu

PLoS One. 2014 Aug 12;9(8):e102394.

PMID: 25115838

1

Preparation of S14161 and Its Analogues and the Discovery of 6-bromo-8-ethoxy-3-nitro-2H-chromene as a More Potent Antitumor Agent in Vitro

Shu-Qiang Yin, Min Shi, Ting-Ting Kong, Cheng-Mei Zhang, Kunkun Han, Biyin Cao, Zubin Zhang, Xiaolin Du, Long-Qian Tang, Xinliang Mao, Zhao-Peng Liu

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3314-9.

PMID: 23601711

1

The Class I PI3K Inhibitor S14161 Induces Autophagy in Malignant Blood Cells by Modulating the Beclin 1/Vps34 Complex

Siyu Wang, Jie Li, Yanyun Du, Yujia Xu, Yali Wang, Zubin Zhang, Zhuan Xu, Yuanying Zeng, Xinliang Mao, Biyin Cao

J Pharmacol Sci. 2017 Aug;134(4):197-202.

PMID: 28779993

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