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S3I-201

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For Research Use Only | Not For Clinical Use
CATAP501919591
CAS501919-59-1
Structure
MDL NumberMFCD09907564
Molecular Weight365.36
InChI KeyHWNUSGNZBAISFM-UHFFFAOYSA-N
Description≥97% (HPLC)
SolubilityDMSO: >10 mg/mL
Assay≥97% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

A Novel STAT3 Inhibitor, S3I-201, Attenuates Renal Interstitial Fibroblast Activation and Interstitial Fibrosis in Obstructive Nephropathy

Maoyin Pang, Li Ma, Rujun Gong, Evelyn Tolbert, Haiping Mao, Murugavel Ponnusamy, Y Eugene Chin, Haidong Yan, Lance D Dworkin, Shougang Zhuang

Kidney Int. 2010 Aug;78(3):257-68.

PMID: 20520592

1

Effects of AG490 and S3I-201 on Regulation of the JAK/STAT3 Signaling Pathway in Relation to Angiogenesis in TRAIL-resistant Prostate Cancer Cells

Venhar Gurbuz, Ece Konac, Nuray Varol, Akin Yilmaz, Serhat Gurocak, Sevda Menevse, Sinan Sozen

Oncol Lett. 2014 Mar;7(3):755-763.

PMID: 24520293

1

S3I-201 Ameliorates Tubulointerstitial Lesion of the Kidneys in MRL/lpr Mice

Yunxia Du, Wei Zhang, Shuxia Liu, Xiaojuan Feng, Fan Gao, Qingjuan Liu

Biochem Biophys Res Commun. 2018 Sep 3;503(1):177-180.

PMID: 29885836

1

S3I-201, a Selective Stat3 Inhibitor, Restores Neuroimmune Function Through Upregulation of Treg Signaling in Autistic BTBR T

Sheikh F Ahmad, Mushtaq A Ansari, Ahmed Nadeem, Saleh A Bakheet, Musaad A Alshammari, Mohammad R Khan, Abdulaziz M S Alsaad, Sabry M Attia

Cell Signal. 2018 Dec;52:127-136.

PMID: 30213685

1

The STAT3 Inhibitor S3I-201 Suppresses Fibrogenesis and Angiogenesis in Liver Fibrosis

Zhuo Wang, Jia'an Li, Wen'ang Xiao, Jiafu Long, Hongmin Zhang

Lab Invest. 2018 Dec;98(12):1600-1613.

PMID: 30206312

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