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SB-207266

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For Research Use Only | Not For Clinical Use
CATAP152811626
CAS152811-62-6
Structure
MDL NumberMFCD00923681
Molecular Weight369.50
InChI KeyKVCSJPATKXABRQ-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 5 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

5-HT4 Receptor Antagonism in Irritable Bowel Syndrome: Effect of SB-207266-A on Rectal Sensitivity and Small Bowel Transit

L A Houghton, N A Jackson, P J Whorwell, S M Cooper

Aliment Pharmacol Ther. 1999 Nov;13(11):1437-44.

PMID: 10571599

1

DSP-6952, a novel 5-HT 4 receptor partial agonist, inhibits visceral hypersensitivity and ameliorates gastrointestinal dysfunction in experimental animals

Yukiko Mine, Tomohiro Itakura, Seiko Oku, Reiko Asada, Isao Shimizu

Eur J Pharmacol. 2018 May 5;826:123-132.

PMID: 29428470

1

Piboserod (SB 207266), a Selective 5-HT4 Receptor Antagonist, Reduces Serotonin Potentiation of Neurally-Mediated Contractile Responses of Human Detrusor Muscle

B Darblade, D Behr-Roussel, D Gorny, T Lebret, G Benoit, J-P Hieble, D Brooks, L Alexandre, F Giuliano

World J Urol. 2005 Jun;23(2):147-51.

PMID: 15902472

1

SB-207266: 5-HT4 Receptor Antagonism in Human Isolated Gut and Prevention of 5-HT-evoked Sensitization of Peristalsis and Increased Defaecation in Animal Models

G J Sanger, S E Banner, M I Smith, K A Wardle

Neurogastroenterol Motil. 1998 Aug;10(4):271-9.

PMID: 9697101

1

Selective and Functional 5-hydroxytryptamine4 Receptor Antagonism by SB 207266

K A Wardle, S Bingham, E S Ellis, L M Gaster, B Rushant, M I Smith, G J Sanger

Br J Pharmacol. 1996 Jun;118(3):665-70.

PMID: 8762092

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