SB 220025

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For Research Use Only | Not For Clinical Use

CAT	AP165806531
CAS	165806-53-1
Molecular Weight	338.38

Description	A cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC₅₀ = 60 nM).
Solubility	DMSO: 22 mg/mL
Assay	≥98% (HPLC)
Color	white to pale yellow
Form	solid; desiccated; protect from light
Size	500μG
Storage Conditions	-20C

Dual Enzyme-Linked Immunosorbent Assay System for Detection of Endogenous Kinase Activities of Mitogen- And Stress-Activated Protein kinase-1/2

Tsuyoshi Ishii, Hiroshi Sootome, Hiroko Toyoda, Mikiya Suda, Takato Noumi, Keizo Yamashita

Assay Drug Dev Technol. 2007 Aug;5(4):523-33.

PMID: 17767420

Intracellular Ca(2+) Signaling in Endothelial Cells by the Angiogenesis Inhibitors Endostatin and Angiostatin

L Jiang, V Jha, M Dhanabal, V P Sukhatme, S L Alper

Am J Physiol Cell Physiol. 2001 May;280(5):C1140-50.

PMID: 11287327

p38 MAPK Regulates Cavitation and Tight Junction Function in the Mouse Blastocyst

Christine E Bell, Andrew J Watson

PLoS One. 2013 Apr 4;8(4):e59528.

PMID: 23593143

Pharmacological Effects of SB 220025, a Selective Inhibitor of P38 Mitogen-Activated Protein Kinase, in Angiogenesis and Chronic Inflammatory Disease Models

J R Jackson, B Bolognese, L Hillegass, S Kassis, J Adams, D E Griswold, J D Winkler

J Pharmacol Exp Ther. 1998 Feb;284(2):687-92.

PMID: 9454815

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