CAS 174635-69-9 SB 222200 - Analytical Products / Alfa Chemistry

CAT	AP174635699
CAS	174635-69-9
MDL Number	MFCD00944072
Molecular Weight	380.48
InChI Key	MQNYRKWJSMQECI-QFIPXVFZSA-N

Description	≥98% (HPLC), solid
Solubility	DMSO: soluble ~28 mg/mL; H2O: insoluble
Assay	≥98% (HPLC)
Color	light yellow
Form	solid
Size	10MG, 50MG
Storage Conditions	2-8°C

1

Blockade of neurokinin-3 Receptors Modulates Dopamine-Mediated Behavioral Hyperactivity

Chinwe A Nwaneshiudu, Ellen M Unterwald

Neuropharmacology. 2009 Sep;57(3):295-301.

PMID: 19500601

1

Effect of a Selective and Potent Central Nervous System Penetrant, neurokinin-3 Receptor Antagonist (SB-222200), on Cisplatin-Induced Emesis in the Ferret

Andrew G King, Gareth J Sanger

Neurosci Lett. 2005 Mar 7;376(1):5-8.

PMID: 15694264

1

Effects of neurokinin-1 and 3-receptor Antagonists on the Defensive Behavior Induced by Electrical Stimulation of the Dorsal Periaqueductal Gray

A C Broiz, G S Bassi, M A De Souza Silva, M L Brandão

Neuroscience. 2012 Jan 10;201:134-45.

PMID: 22123168

1

Nonpeptide Tachykinin Receptor Antagonists. II. Pharmacological and Pharmacokinetic Profile of SB-222200, a Central Nervous System Penetrant, Potent and Selective NK-3 Receptor Antagonist

H M Sarau, D E Griswold, B Bush, W Potts, P Sandhu, D Lundberg, J J Foley, D B Schmidt, E F Webb, L D Martin, J J Legos, R G Whitmore, F C Barone, A D Medhurst, M A Luttmann, G A Giardina, D W Hay

J Pharmacol Exp Ther. 2000 Oct;295(1):373-81.

PMID: 10992004

1

Tachykinin NK3 Receptor Contribution to Systemic Release of Vasopressin and Oxytocin in Response to Osmotic and Hypotensive Challenge

Gwendolen E Haley, Francis W Flynn

Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R931-7.

PMID: 17522129

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