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SB-590885

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For Research Use Only | Not For Clinical Use
CATAP405554554
CAS405554-55-4
Structure
MDL NumberMFCD16038645
Molecular Weight453.54
InChI KeyMLSAQOINCGAULQ-QLTSDVKISA-N
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL (clear solution, warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K

Jessie Villanueva, Adina Vultur, John T Lee, Rajasekharan Somasundaram, Mizuho Fukunaga-Kalabis, Angela K Cipolla, Bradley Wubbenhorst, Xiaowei Xu, Phyllis A Gimotty, Damien Kee, Ademi E Santiago-Walker, etc.

Cancer Cell. 2010 Dec 14;18(6):683-95.

PMID: 21156289

1

Concentration-Dependent Dual Effects of Ciprofloxacin on SB-590885-Resistant BRAF

Seyyede Araste Aldaghi, Razieh Jalal

Chem Res Toxicol. 2019 Apr 15;32(4):645-658.

PMID: 30829029

1

Demonstration of a Genetic Therapeutic Index for Tumors Expressing Oncogenic BRAF by the Kinase Inhibitor SB-590885

Alastair J King, Denis R Patrick, Roberta S Batorsky, Maureen L Ho, Hieu T Do, Shu Yun Zhang, Rakesh Kumar, David W Rusnak, Andrew K Takle, David M Wilson, Erin Hugger, Lifu Wang, Florian Karreth, Julie C Lougheed, etc.

Cancer Res. 2006 Dec 1;66(23):11100-5.

PMID: 17145850

1

Human Cerebrovascular Contractile Receptors Are Upregulated via a B-Raf/MEK/ERK-sensitive Signaling Pathway

Hilda Ahnstedt, Hans Säveland, Ola Nilsson, Lars Edvinsson

BMC Neurosci. 2011 Jan 11;12:5.

PMID: 21223556

1

The Identification of Potent and Selective Imidazole-Based Inhibitors of B-Raf Kinase

Andrew K Takle, Murray J B Brown, Susannah Davies, David K Dean, Gerraint Francis, Alessandra Gaiba, Alex W Hird, Frank D King, Peter J Lovell, Antoinette Naylor, Alastair D Reith, Jon G Steadman, David M Wilson

Bioorg Med Chem Lett. 2006 Jan 15;16(2):378-81.

PMID: 16260133

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