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SB269652

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For Research Use Only | Not For Clinical Use
CATAP215802156
CAS215802-15-6
Structure
Molecular Weight426.55
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

A New Mechanism of Allostery in a G Protein-Coupled Receptor Dimer

J Robert Lane, Prashant Donthamsetti, Jeremy Shonberg, Christopher J Draper-Joyce, Samuel Dentry, Mayako Michino, Lei Shi, Laura López, Peter J Scammells, Ben Capuano, Patrick M Sexton, Jonathan A Javitch, etc.

Nat Chem Biol. 2014 Sep;10(9):745-52.

PMID: 25108820

1

Structure-activity Study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a Bitopic Ligand That Acts as a Negative Allosteric Modulator of the Dopamine D2 Receptor

Jeremy Shonberg, Christopher Draper-Joyce, Shailesh N Mistry, Arthur Christopoulos, Peter J Scammells, J Robert Lane, Ben Capuano

J Med Chem. 2015 Jul 9;58(13):5287-307.

PMID: 26052807

1

The Action of a Negative Allosteric Modulator at the Dopamine D

Christopher J Draper-Joyce, Ravi Kumar Verma, Mayako Michino, Jeremy Shonberg, Anitha Kopinathan, Carmen Klein Herenbrink, Peter J Scammells, Ben Capuano, Ara M Abramyan, David M Thal, Jonathan A Javitch, etc.

Sci Rep. 2018 Jan 19;8(1):1208.

PMID: 29352161

1

The E2.65A Mutation Disrupts Dynamic Binding Poses of SB269652 at the Dopamine D2 and D3 Receptors

Ravi Kumar Verma, Ara M Abramyan, Mayako Michino, R Benjamin Free, David R Sibley, Jonathan A Javitch, J Robert Lane, Lei Shi

PLoS Comput Biol. 2018 Jan 16;14(1):e1005948.

PMID: 29337986

1

The Structural Determinants of the Bitopic Binding Mode of a Negative Allosteric Modulator of the Dopamine D

Christopher J Draper-Joyce, Mayako Michino, Ravi Kumar Verma, Carmen Klein Herenbrink, Jeremy Shonberg, Anitha Kopinathan, Peter J Scammells, Ben Capuano, David M Thal, Jonathan A Javitch, Arthur Christopoulos, etc.

Biochem Pharmacol. 2018 Feb;148:315-328.

PMID: 29325769

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