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SBI-0206965

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For Research Use Only | Not For Clinical Use
CATIAR4245182
Molecular Weight489.32
InChI KeyNEXGBSJERNQRSV-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

AMP-activated Protein Kinase Selectively Inhibited by the Type II Inhibitor SBI-0206965

Toby A Dite, Christopher G Langendorf, Ashfaqul Hoque, Sandra Galic, Richard J Rebello, Ashley J Ovens, Lisa M Lindqvist, Kevin R W Ngoei, Naomi X Y Ling, Luc Furic, Bruce E Kemp, John W Scott, Jonathan S Oakhill

J Biol Chem. 2018 Jun 8;293(23):8874-8885.

PMID: 29695504

1

Irisin Alleviates Pressure Overload-Induced Cardiac Hypertrophy by Inducing Protective Autophagy via mTOR-independent Activation of the AMPK-ULK1 Pathway

Ru-Li Li, Si-Si Wu, Yao Wu, Xiao-Xiao Wang, Hong-Ying Chen, Juan-Juan Xin, He Li, Jie Lan, Kun-Yue Xue, Xue Li, Cai-Li Zhuo, Yu-Yan Cai, Jin-Han He, Heng-Yu Zhang, Chao-Shu Tang, Wang Wang, Wei Jiang

J Mol Cell Cardiol. 2018 Aug;121:242-255.

PMID: 30053525

1

Overexpression of ULK1 Represents a Potential Diagnostic Marker for Clear Cell Renal Carcinoma and the Antitumor Effects of SBI-0206965

Jun Lu, Ling Zhu, Luo-Ping Zheng, Qiang Cui, He-Huan Zhu, Hu Zhao, Zhou-Ji Shen, Hui-Yue Dong, Shu-Shang Chen, Wei-Zhen Wu, Jian-Ming Tan

EBioMedicine. 2018 Aug;34:85-93.

PMID: 30078736

1

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

Daniel F Egan, Matthew G H Chun, Mitchell Vamos, Haixia Zou, Juan Rong, Chad J Miller, Hua Jane Lou, Dhanya Raveendra-Panickar, Chih-Cheng Yang, Douglas J Sheffler, Peter Teriete, John M Asara, Benjamin E Turk, etc.

Mol Cell. 2015 Jul 16;59(2):285-97.

PMID: 26118643

1

Targeted Inhibition of ULK1 Promotes Apoptosis and Suppresses Tumor Growth and Metastasis in Neuroblastoma

Christopher M Dower, Neema Bhat, Melat T Gebru, Longgui Chen, Carson A Wills, Barbara A Miller, Hong-Gang Wang

Mol Cancer Ther. 2018 Nov;17(11):2365-2376.

PMID: 30166400

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