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SC-236

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For Research Use Only | Not For Clinical Use
CATAP170569865
CAS170569-86-5
MDL NumberMFCD00941297
Molecular Weight401.79
InChI KeyNSQNZEUFHPTJME-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: >20 mg/mL
Assay≥98% (HPLC)
Colorwhite to off-white
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Cyclooxygenase-2 Inhibitor (SC-236) Suppresses Activator protein-1 Through c-Jun NH2-terminal Kinase

Benjamin Chun-Yu Wong, Xiao Hua Jiang, Marie C m Lin, Shui Ping Tu, Jian Tao Cui, Shi Hu Jiang, Wai Man Wong, Man Fung Yuen, Shiu Kum Lam, Hsiang Fu Kung

Gastroenterology. 2004 Jan;126(1):136-47.

PMID: 14699495

1

Cyclooxygenase-2 Inhibitor SC-236 [4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l] Benzenesulfonamide] Suppresses Nuclear factor-kappaB Activation and Phosphorylation of p38 Mitogen-Activated Protein Kinase, Extracellular Signal-Regulated Kinase, and c-Jun N-terminal Kinase in Human Mast Cell Line Cells

Su-Jin Kim, Hyun-Ja Jeong, In-Young Choi, Kang-Min Lee, Rae-Kil Park, Seung-Heon Hong, Hyung-Min Kim

J Pharmacol Exp Ther. 2005 Jul;314(1):27-34.

PMID: 15784648

1

The COX-2 Inhibitor SC-236 Exerts Anti-Inflammatory Effects by Suppressing Phosphorylation of ERK in a Murine Model

Su-Jin Kim, Hyun-Ja Jeong, Phil-Dong Moon, Noh-Yil Myung, Min-Cheol Kim, Tae-Hee Kang, Kang-Min Lee, Rae-Kil Park, Hong-seob So, Eun-Cheol Kim, Nyeon-Hyoung An, Jae-Young Um, Hyung-Min Kim, Seung-Heon Hong

Life Sci. 2007 Aug 23;81(11):863-72.

PMID: 17822719

1

The Regulatory Effect of SC-236 (4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l]benzenesulfonamide) on Stem Cell Factor Induced Migration of Mast Cells

Su-Jin Kim, Hyun-Ja Jeong, Rae-Kil Park, Kang-Min Lee, Hyung-Min Kim, Jae-Young Um, Seung-Heon Hong

Toxicol Appl Pharmacol. 2007 Apr 15;220(2):138-45.

PMID: 17320132

1

The Selective cyclooxygenase-2 Inhibitor SC-236 Reduces Liver Fibrosis by Mechanisms Involving Non-Parenchymal Cell Apoptosis and PPARgamma Activation

Anna Planagumà, Joan Clària, Rosa Miquel, Marta López-Parra, Esther Titos, Jaime L Masferrer, Vicente Arroyo, Joan Rodés

FASEB J. 2005 Jul;19(9):1120-2.

PMID: 15876570

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