CAS 871361-88-5 SC66 - Analytical Products / Alfa Chemistry

CAT	AP871361885
CAS	871361-88-5
MDL Number	MFCD05025493
Molecular Weight	276.33
InChI Key	CYVVJSKZRBZHAV-UNZYHPAISA-N

Description	≥98% (HPLC)
Solubility	DMSO: ≥5 mg/mL (warmed)
Assay	≥98% (HPLC)
Color	faintly yellow to dark yellow
Form	powder
Size	25MG
Storage Conditions	2-8°C

1

Akt Inhibitor SC66 Promotes Cell Sensitivity to Cisplatin in Chemoresistant Ovarian Cancer Cells Through Inhibition of COL11A1 Expression

Yi-Hui Wu, Yu-Fang Huang, Chien-Chin Chen, Cheng-Yang Chou

Cell Death Dis. 2019 Apr 11;10(4):322.

PMID: 30975980

1

Cytotoxic Activity of the Novel Small Molecule AKT Inhibitor SC66 in Hepatocellular Carcinoma Cells

Antonella Cusimano, Roberto Puleio, Natale D'Alessandro, Guido R Loria, James A McCubrey, Giuseppe Montalto, Melchiorre Cervello

Oncotarget. 2015 Jan 30;6(3):1707-22.

PMID: 25596737

1

Deactivation of Akt by a Small Molecule Inhibitor Targeting Pleckstrin Homology Domain and Facilitating Akt Ubiquitination

Hakryul Jo, Pang-Kuo Lo, Yitang Li, Fabien Loison, Sarah Green, Jake Wang, Leslie E Silberstein, Keqiang Ye, Hexin Chen, Hongbo R Luo

Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6486-91.

PMID: 21464312

1

Protein Kinase B/AKT Mediates Insulin-Like Growth Factor 1-induced Phosphorylation and Nuclear Export of Histone Deacetylase 5 via NADPH Oxidase 4 Activation in Vascular Smooth Muscle Cells

Paulina Pietruczuk, Ashish Jain, Estelle R Simo-Cheyou, Madhu B Anand-Srivastava, Ashok K Srivastava

J Cell Physiol. 2019 Aug;234(10):17337-17350.

PMID: 30793765

1

Targeting Akt by SC66 Triggers GSK-3β Mediated Apoptosis in Colon Cancer Therapy

Yeying Liu, Yuan Huang, Jie Ding, Nannan Liu, Shuang Peng, Jiangang Wang, Feng Wang, Yingjie Zhang

Cancer Cell Int. 2019 May 9;19:124.

PMID: 31168297

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