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Sephin1

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For Research Use Only | Not For Clinical Use
CATAP951441046
CAS951441-04-6
MDL NumberMFCD00790608
Molecular Weight196.64
InChI KeyPDWJALXSRRSUHR-LFYBBSHMSA-N
Description≥95% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥95% (HPLC)
Colorwhite to beige
Formpowder
Size10MG
Storage Conditions2-8°C
1

Decoding the Selectivity of eIF2α Holophosphatases and PPP1R15A Inhibitors

Marta Carrara, Anna Sigurdardottir, Anne Bertolotti

Nat Struct Mol Biol. 2017 Sep;24(9):708-716.

PMID: 28759048

1

Evaluation of the Antiviral Activity of Sephin1 Treatment and Its Consequences on eIF2α Phosphorylation in Response to Viral Infections

Maxime Fusade-Boyer, Gabriel Dupré, Pierre Bessière, Samira Khiar, Charlotte Quentin-Froignant, Cécile Beck, Sylvie Lecollinet, Marie-Anne Rameix-Welti, Jean-François Eléouët, Frédéric Tangy, Barbora Lajoie, etc.

Front Immunol. 2019 Feb 12;10:134.

PMID: 30809223

1

Preventing Proteostasis Diseases by Selective Inhibition of a Phosphatase Regulatory Subunit

Indrajit Das, Agnieszka Krzyzosiak, Kim Schneider, Lawrence Wrabetz, Maurizio D'Antonio, Nicholas Barry, Anna Sigurdardottir, Anne Bertolotti

Science. 2015 Apr 10;348(6231):239-42.

PMID: 25859045

1

Sephin1, Which Prolongs the Integrated Stress Response, Is a Promising Therapeutic for Multiple Sclerosis

Yanan Chen, Joseph R Podojil, Rejani B Kunjamma, Joshua Jones, Molly Weiner, Wensheng Lin, Stephen D Miller, Brian Popko

Brain. 2019 Feb 1;142(2):344-361.

PMID: 30657878

1

Targeting Super-Enhancer-Driven Oncogenic Transcription by CDK7 Inhibition in Anaplastic Thyroid Carcinoma

Xinyi Cao, Lin Dang, Xiangqian Zheng, Yi Lu, Yumei Lu, Rongjie Ji, Tianye Zhang, Xianhui Ruan, Jingtai Zhi, Xiukun Hou, Xianfu Yi, Mulin Jun Li, Tingyu Gu, Ming Gao, Lirong Zhang, Yupeng Chen

Thyroid. 2019 Jun;29(6):809-823.

PMID: 30924726

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