Set8 Active human

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For Research Use Only | Not For Clinical Use

CAT

IAR42416090

Description	recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
Assay	≥70% (SDS-PAGE)
Form	aqueous solution
Size	50μG
Storage Conditions	−70°C

Inactivation of the CRL4-CDT2-SET8/p21 Ubiquitylation and Degradation Axis Underlies the Therapeutic Efficacy of Pevonedistat in Melanoma

Mouadh Benamar, Fadila Guessous, Kangping Du, Patrick Corbett, Joseph Obeid, Daniel Gioeli, Craig L Slingluff Jr, Tarek Abbas

EBioMedicine. 2016 Aug;10:85-100.

PMID: 27333051

SCF(β-TRCP) Promotes Cell Growth by Targeting PR-Set7/Set8 for Degradation

Zhiwei Wang, Xiangpeng Dai, Jiateng Zhong, Hiroyuki Inuzuka, Lixin Wan, Xiaoning Li, Lixia Wang, Xiantao Ye, Liankun Sun, Daming Gao, Lee Zou, Wenyi Wei

Nat Commun. 2015 Dec 15;6:10185.

PMID: 26666832

SET8 Induces epithelial‑mesenchymal Transition and Enhances Prostate Cancer Cell Metastasis by Cooperating With ZEB1

Liejun Hou, Qiang Li, Yiming Yu, Ming Li, Dayong Zhang

Mol Med Rep. 2016 Feb;13(2):1681-8.

PMID: 26717907

SET8 Methyltransferase Activity During the DNA Double-Strand Break Response Is Required for Recruitment of 53BP1

Stanimir Dulev, Johnny Tkach, Sichun Lin, Nizar N Batada

EMBO Rep. 2014 Nov;15(11):1163-74.

PMID: 25252681

The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers

Shashi Kiran, Ashraf Dar, Samarendra K Singh, Kyung Yong Lee, Anindya Dutta

Mol Cell. 2018 Dec 6;72(5):823-835.e5.

PMID: 30415951

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