SGC707

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For Research Use Only | Not For Clinical Use

CAT	IAR4245160
Molecular Weight	298.34
InChI Key	DMIDPTCQPIJYFE-UHFFFAOYSA-N

Description	≥98% (HPLC)
Solubility	DMSO: 20 mg/mL, clear
Assay	≥98% (HPLC)
Color	white to light brown
Form	powder
Size	5MG, 25MG
Storage Conditions	2-8°C

A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)

H Ümit Kaniskan, Magdalena M Szewczyk, Zhengtian Yu, Mohammad S Eram, Xiaobao Yang, Keith Schmidt, Xiao Luo, Miao Dai, Feng He, Irene Zang, Ying Lin, Steven Kennedy, Fengling Li, Elena Dobrovetsky, Aiping Dong, etc.

Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5166-70.

PMID: 25728001

Asymmetrical Methyltransferase PRMT3 Regulates Human Mesenchymal Stem Cell Osteogenesis via miR-3648

Zhang Min, Liu Xiaomeng, Li Zheng, Du Yangge, Liu Xuejiao, Lv Longwei, Zhang Xiao, Liu Yunsong, Zhang Ping, Zhou Yongsheng

Cell Death Dis. 2019 Aug 5;10(8):581.

PMID: 31378783

Inhibition of PRMT3 Activity Reduces Hepatic Steatosis Without Altering Atherosclerosis Susceptibility in apoE Knockout Mice

Menno Hoekstra, Joya E Nahon, Laura M de Jong, Mara J Kröner, Lidewij R de Leeuw, Miranda Van Eck

Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1402-1409.

PMID: 30776415

Inhibition of Protein Arginine Methyltransferase 3 Activity Selectively Impairs Liver X Receptor-Driven Transcription of Hepatic Lipogenic Genes in Vivo

Joya E Nahon, Christianne Groeneveldt, Janine J Geerling, Miranda van Eck, Menno Hoekstra

Br J Pharmacol. 2018 Aug;175(15):3175-3183.

PMID: 29774529

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