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SGI-1027

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For Research Use Only | Not For Clinical Use
CATAP1020149738
CAS1020149-73-8
MDL NumberMFCD27937047
Molecular Weight461.52
InChI KeyQSYLKMKIVWJAAK-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to light brown
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

[Effects of SGI-1027 on Formation and Elimination of PrP^(Sc) in Prion-Infected Cells]

J J Li, C S Ryou, D-H Kim

Mol Biol (Mosk). May-Jun 2020;54(3):469-473.

PMID: 32492010

1

Design, Synthesis and Biological Evaluation of 4-amino-N- (4-aminophenyl)benzamide Analogues of Quinoline-Based SGI-1027 as Inhibitors of DNA Methylation

Elodie Rilova, Alexandre Erdmann, Christina Gros, Véronique Masson, Yannick Aussagues, Valérie Poughon-Cassabois, Arumugam Rajavelu, Albert Jeltsch, Yoann Menon, Natacha Novosad, Jean-Marc Gregoire, Stéphane Vispé, etc.

ChemMedChem. 2014 Mar;9(3):590-601.

PMID: 24678024

1

DNMTs Inhibitor SGI-1027 Induces Apoptosis in Huh7 Human Hepatocellular Carcinoma Cells

Ning Sun, Jialin Zhang, Chengshuo Zhang, Bochao Zhao, Ao Jiao

Oncol Lett. 2018 Nov;16(5):5799-5806.

PMID: 30344731

1

Molecular Modeling Studies of the Novel Inhibitors of DNA Methyltransferases SGI-1027 and CBC12: Implications for the Mechanism of Inhibition of DNMTs

Jakyung Yoo, Sun Choi, José L Medina-Franco

PLoS One. 2013 Apr 25;8(4):e62152.

PMID: 23637988

1

Synthetic Approaches to DNMT Inhibitor SGI-1027 and Effects on the U937 Leukemia Cell Line

Patricia García-Domínguez, Carmela Dell'aversana, Rosana Alvarez, Lucia Altucci, Angel R de Lera

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1631-5.

PMID: 23402879

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