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SIB 1893

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For Research Use Only | Not For Clinical Use
CATAP7370210
CAS7370-21-0
MDL NumberMFCD02262120
Molecular Weight195.26
InChI KeySISOFUCTXZKSOQ-ZHACJKMWSA-N
Description>99%, solid
SolubilityDMSO: 18 mg/mL
Assay>99%
Formsolid
Size10MG
Storage Conditions2-8°C
1

Development of Allosteric Modulators of GPCRs for Treatment of CNS Disorders

Hilary Highfield Nickols, P Jeffrey Conn

Neurobiol Dis. 2014 Jan;61:55-71.

PMID: 24076101

1

Influence of SIB 1893, a Selective mGluR5 Receptor Antagonist, on the Anticonvulsant Activity of Conventional Antiepileptic Drugs in Two Models of Experimental Epilepsy

Kinga K Borowicz, Barbara Piskorska, J Łuszczki, Stanisław J Czuczwar

Pol J Pharmacol. Sep-Oct 2003;55(5):735-40.

PMID: 14704469

1

Methylphenylethynylpyridine (MPEP) Novartis

F Micheli

Curr Opin Investig Drugs. 2000 Nov;1(3):355-9.

PMID: 11249719

1

Positive Allosteric Modulation of the Human Metabotropic Glutamate Receptor 4 (hmGluR4) by SIB-1893 and MPEP

Jesper Mosolff Mathiesen, Nannette Svendsen, Hans Bräuner-Osborne, Christian Thomsen, M Teresa Ramirez

Br J Pharmacol. 2003 Mar;138(6):1026-30.

PMID: 12684257

1

SIB-1757 and SIB-1893: Selective, Noncompetitive Antagonists of Metabotropic Glutamate Receptor Type 5

M A Varney, N D Cosford, C Jachec, S P Rao, A Sacaan, F F Lin, L Bleicher, E M Santori, P J Flor, H Allgeier, F Gasparini, R Kuhn, S D Hess, G Veliçelebi, E C Johnson

J Pharmacol Exp Ther. 1999 Jul;290(1):170-81.

PMID: 10381773

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